| Efficacy of morning-only compared with split-dose polyethylene glycol electrolyte solution for afternoon colonoscopy: a randomized controlled single-blind study. | |
| | |
MedLine Citation:
|
PMID: 20407434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Administering a purgative close to the time of colonoscopy is optimal for cleansing. The aim of this study was to compare the efficacy and tolerability of morning-only (AM-only) polyethylene glycol electrolyte solution (PEG-ELS) to split-dose (PM/AM) PEG-ELS for afternoon colonoscopy. METHODS: This was a single-center, prospective, randomized, investigator-blinded, non-inferiority study comparing AM-only to PM/AM PEG-ELS for afternoon outpatient colonoscopy. The primary end point was whole colon prep adequacy. Tolerance and polyp detection were secondary outcomes. RESULTS: Overall, 125 patients were randomized and 9 withdrew without taking any prep. Of 116 analyzed, 62 received AM-only prep and 54 received PM/AM prep. The whole colon prep was adequate in 92% in the AM-only group vs. 94% in the PM/AM group (95% lower confidence limit, LCL, for the difference=-11.3%, non-inferiority P=0.013), whereas the right colon prep was adequate in 93 and 92%, respectively (95% LCL=-7.8%, non-inferiority P=0.003). Polyp detection was greater, and not inferior, in the AM-only group (mean=1.57 vs. 0.94 polyps/patient, non-inferiority P=0.007). The overall incidence of adverse events was not significantly different between the two groups (P=0.273), but the AM-only group had lower incidence of abdominal pain (P=0.024). The AM-only group also had better sleep quality (P=0.007) and less interference with the previous workday (P=0.019). CONCLUSIONS: AM-only and PM/AM PEG-ELS are clinically equivalent with respect to cleansing efficacy and polyp detection. AM-only prep was associated with a lower incidence of abdominal pain, superior sleep quality, and less interference with workday before colonoscopy. |
| | |
Authors:
|
Rebecca Matro; Anastasia Shnitser; Maya Spodik; Constantine Daskalakis; Leo Katz; Alexandra Murtha; David Kastenberg |
Related Documents
:
|
20959374 - Non-laxative ct colonography with barium-based faecal tagging: is additional phosphate ... 12098034 - Laparoscopically assisted subtotal colectomy with antiperistaltic cecorectal anastomosis. 19184064 - Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resec... 7031214 - Group g streptococcal colonization and sepsis in neonates. 22045054 - Radical cystectomy in patients over 70 years of age: impact of comorbidity on perioper... 17706004 - Darifenacin treatment of patients >or= 65 years with overactive bladder: results of a r... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial Date: 2010-04-20 |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: 105 ISSN: 1572-0241 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-06 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: 1954-61 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Adult Aged Cathartics / administration & dosage, therapeutic use Colonoscopy / methods* Female Humans Male Middle Aged Patient Selection Polyethylene Glycols / administration & dosage*, therapeutic use Prospective Studies Single-Blind Method Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Cathartics; 0/Polyethylene Glycols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Autoantibodies against the exocrine pancreas in autoimmune pancreatitis: gene and protein expression...
Next Document: Putting brain training to the test.