Document Detail

Efficacy of medical expulsive treatment with doxazosin in pediatric patients.
MedLine Citation:
PMID:  23343614     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the possible efficacy of an α1 blocker (doxazosin) therapy on the management and disease course in pediatric patients with distal ureteral stones.
MATERIALS AND METHODS: A total of 45 patients (24 boys and 21 girls) with a single lower ureteral stone were included in the study program. Their age range was 3-15 years (mean 6.65 ± 3.78). The children were randomized into 2 main groups: group 1 (n = 21), who received only ibuprofen 20 mg/kg/d divided into 2 equal doses for pain control during follow-up; and group 2 (n = 24), who received, in addition to ibuprofen, 0.03 mg/kg/d doxazosin once daily, before bed.
RESULTS: The stone expulsion rate was 28.5% (6 of 21) in group 1 and 70.8% (17 of 24) in group 2 (P = .001). The number of daily colic attacks and stone expulsion time clearly demonstrated the advantage of doxazosin, with a statistically significant diminished number of pain attacks (P = .04) and shorter stone expulsion period (P = .001). Stones <5 mm were expulsed at greater rates than stones 5-10 mm in group 2 (P = .046). Also children aged <6 years passed the stones with significantly greater rates than children aged ≥7 years (P = .008).
CONCLUSION: The use of α-adrenergic blocker agents could have certain advantages in attempts to render children stone free within a shorter period, which would inevitably diminish the number of colic attacks and the need for analgesic usage.
Sakip Erturhan; Omer Bayrak; Kemal Sarica; Ilker Seckiner; Muharrem Baturu; Haluk Sen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2013-01-21
Journal Detail:
Title:  Urology     Volume:  81     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-04-22     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  640-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Department of Urology, Gaziantep University, Gaziantep, Turkey.
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MeSH Terms
Adrenergic alpha-1 Receptor Antagonists / therapeutic use*
Child, Preschool
Doxazosin / therapeutic use*
Treatment Outcome
Ureteral Calculi / drug therapy*
Reg. No./Substance:
0/Adrenergic alpha-1 Receptor Antagonists; 74191-85-8/Doxazosin
Comment In:
Urology. 2013 Jun;81(6):1381   [PMID:  23726453 ]
Urology. 2013 Jun;81(6):1381-2   [PMID:  23726452 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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