Document Detail


Efficacy of an MPC-BMA co-polymer as a nanotransporter for paclitaxel.
MedLine Citation:
PMID:  17595758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Paclitaxel (PTX) is administered as a solution in polyoxyethylated castor oil (CO) due to its low water solubility, but solvent-induced side-effects may be severe. MATERIALS AND METHODS: PMB30W is a co-polymer of 2-methacryloyloxyethyl phosphorylcholine (MPC) and butyl methacrylate (BMA). Cytotoxicities of PTX in PMB30W (PTX-PMB30W) were examined in cell culture and in vivo. RESULTS: PTX-PMB30W and PTX in dimethyl sulfoxide showed similar toxicity in breast cancer cell lines MCF-7, SK-BR-3 and MX-1. Antitumor efficacies of PTX-PMB30W and PTX in CO (PTX-CO) were similar following weekly intraperitoneal administration of 50 mg/kg PTX in nude mice transplanted with MX-1 cells. At 200 mg/kg PTX, all animals died within 1 minute of PTX-CO administration. However, all animals receiving PTX-PBM30W survived. Ulceration occurred following subcutaneous injection of PTX-CO, but injection of PTX-PMB30W did not cause skin changes. CONCLUSION: Our data suggest that PMB30W can act as an effective PTX nanotransporter.
Authors:
Masahiro Wada; Hiromitsu Jinno; Masakazu Ueda; Tadashi Ikeda; Masaki Kitajima; Tomohiro Konno; Junji Watanabe; Kazuhiko Ishihara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  27     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-06-28     Completed Date:  2007-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1431-5     Citation Subset:  IM    
Affiliation:
Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / administration & dosage*,  chemistry
Dimethyl Sulfoxide / chemistry,  toxicity
Drug Carriers / administration & dosage*,  chemistry,  toxicity
Female
Humans
Methacrylates / administration & dosage*,  chemistry,  toxicity
Mice
Mice, Nude
Nanocapsules / administration & dosage*,  chemistry,  toxicity
Paclitaxel / administration & dosage*,  chemistry
Phosphorylcholine / administration & dosage,  analogs & derivatives*,  chemistry,  toxicity
Skin / drug effects,  pathology
Skin Ulcer / chemically induced,  pathology
Xenograft Model Antitumor Assays
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Drug Carriers; 0/Methacrylates; 0/Nanocapsules; 107-73-3/Phosphorylcholine; 125275-25-4/poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate); 33069-62-4/Paclitaxel; 67-68-5/Dimethyl Sulfoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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