Document Detail

Efficacy of Listerine, Meridol and chlorhexidine mouthrinses on plaque, gingivitis and plaque bacteria vitality.
MedLine Citation:
PMID:  2355095     Owner:  NLM     Status:  MEDLINE    
The experimental gingivitis model was used to compare the anti-plaque, anti-gingivitis and anti-microbial efficacies of a phenolic compound (Listerine) and an amine/stannous fluoride mouthwash (Meridol), using a placebo preparation as negative control and a chlorhexidine solution as positive control in a double-blind study. After professional toothcleaning, 36 volunteers performed optimal oral hygiene for a period of 2 weeks. They then ceased all oral hygiene procedures for 21 days during which they rinsed twice daily with 1 of the 4 mouthrinses. After 3 weeks of rinsing, plaque indices remained the lowest in the chlorhexidine group, while subjects using Listerine or Meridol harbored similar indices significantly lower than that of individuals rinsing with the placebo solution. Up to that time, the gingival index scores were equal in all groups except for the chlorhexidine group in which the values only amounted to half of these encountered in the other groups. The plaque vitality scores showed a bactericidal effect in vivo of chlorhexidine during the entire time of experimental gingivitis. In contrast, the data gave no evidence of an antibacterial effect in vivo of Listerine. The efficacy of Meridol to kill micro-organisms was similar to chlorhexidine during the early stages of plaque accumulation and, with time, became insignificant. This study has demonstrated that chlorhexidine was superior to Listerine and Meridol in its ability to maintain low plaque scores and gingival health during this 3-week period of no mechanical oral hygiene. Moreover, it was also shown that Meridol was as effective as Listerine in reducing plaque accumulation and, in contrast to Listerine, possessed a remarkable but transient antibacterial effect in vivo.
M Brecx; L Netuschil; B Reichert; G Schreil
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  17     ISSN:  0303-6979     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-07-20     Completed Date:  1990-07-20     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  292-7     Citation Subset:  D; IM    
Department of Conservative Dentistry, School of Dental Medicine, University of Tübingen, FRG.
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MeSH Terms
Amines / therapeutic use*
Chlorhexidine / analogs & derivatives,  therapeutic use
Dental Plaque / drug therapy*,  microbiology
Double-Blind Method
Drug Combinations / therapeutic use
Fluorides / therapeutic use*
Gingivitis / drug therapy*
Microbial Sensitivity Tests
Microscopy, Fluorescence
Mouthwashes / therapeutic use*
Product Surveillance, Postmarketing
Salicylates / therapeutic use*
Terpenes / therapeutic use*
Tin Fluorides*
Reg. No./Substance:
0/Amines; 0/Drug Combinations; 0/Fluorides; 0/Mouthwashes; 0/Salicylates; 0/Terpenes; 0/Tin Fluorides; 120812-75-1/Meridol; 51273-66-6/Listerine; 55-56-1/Chlorhexidine; MOR84MUD8E/chlorhexidine gluconate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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