| Efficacy of intralesional bevacizumab injection in decreasing pterygium size. | |
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MedLine Citation:
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PMID: 20885313 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the efficacy of intralesional bevacizumab injection in decreasing size of pterygium. METHODS: Seventeen patients with pterygium (14 with primary and 3 with recurrent pterygium) received intralesional injections of bevacizumab (2.5 mg/0.1 mL). Digital photographs were analyzed by image analysis software to determine the change of corneal involvement as a percentage of the total corneal surface. RESULTS: The mean age of the patients was 45.5 ± 15.8 years. The mean percentage size of lesions before injection was 17.2% ± 4.3% of corneal surface. The mean percentage size of lesions 1 week, 1 month, and 3 months after injection was 15.1% ± 4.3%, 13.4% ± 4.0%, and 14.1% ± 4.4% of corneal surface, respectively. The mean percentage decrease of lesion size was 3.97% ± 3.84%. There were statistically significant differences between percentage of lesion size before and 1 week (P < 0.001), 1 month (P < 0.001), and 3 months (P < 0.001) after injection of bevacizumab. There were neither postinjection ocular complications such as rise of intraocular pressure nor systemic adverse events. Visual acuity did not change after injection of bevacizumab. Despite statistically significant decrease in pterygium size, this decrease does not seem to be clinically significant. CONCLUSIONS: Intralesional bevacizumab injection is fairly effective in reducing the size of pterygium and is well tolerated; however, this effect is not clinically significant. |
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Authors:
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Mohammad Reza Fallah Tafti; Keivan Khosravifard; Mehrdad Mohammadpour; Mohammad Naser Hashemian; Mohammad Yaser Kiarudi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cornea Volume: 30 ISSN: 1536-4798 ISO Abbreviation: Cornea Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 127-9 Citation Subset: IM |
Affiliation:
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Eye Research Center, Farabi Eye Hospital, Cornea Department, Tehran University of Medical Sciences, Tehran, Iran. mahammadpour@yahoo.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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