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Efficacy of IV Iron Compared to Oral Iron for Increment of Haemoglobin Level in Anemic Chronic Kidney Disease Patients on Erythropoietin Therapy.
MedLine Citation:
PMID:  22922860     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Introduction: Anemia is the most common finding in chronic kidney disease patients. Iron supplements are commonly prescribed for these patients with or without erythropoietin therapy by means of oral and intravenous iron. Both oral and intravenous irons have their own advantage and disadvantage, and the efficacy is also different. The objective of the study is to analyze the efficacy of oral and intravenous iron in chronic kidney disease patients on erythropoietin therapy, an erythropoiesis stimulating agents for increment of haemoglobin. Methods: This is a prospective study comparing intravenous iron to oral iron in chronic kidney disease patients who underwent maintenance hemodialysis at different centers and visited Kathmandu Medical College Teaching Hospital from April 2010 to April 2011. Patients having a haemoglobin level of < 11 g/dl, transferrin saturation (TSAT) < 25%, ferritin < 300ng/ml and who were on erythropoietin therapy were allocated alternately into two groups to receive oral iron (iron fumarate) or IV iron (iv sucrose). Haemoglobin was measured after 30 days of therapy. Results: A significant increase in haemoglobin levels was observed in both groups. But the mean haemoglobin increment was more in the IV iron group than in the oral iron group. Sixty percent 60% of patients in the IV iron group had an increase in the haemoglobin level of more than 1gm/dl while only 20% of the oral iron group had this increase. Conclusions: Intravenous iron therapy is more effective in raising the hemoglobin level in hemodialysis dependent chronic kidney disease patients.
Authors:
L Adhikary; S Acharya
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JNMA; journal of the Nepal Medical Association     Volume:  51     ISSN:  0028-2715     ISO Abbreviation:  JNMA J Nepal Med Assoc     Publication Date:    2011 Jul-Sep
Date Detail:
Created Date:  2012-08-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045233     Medline TA:  JNMA J Nepal Med Assoc     Country:  Nepal    
Other Details:
Languages:  eng     Pagination:  133-6     Citation Subset:  IM    
Affiliation:
Department of Medicine, Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal.
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