| Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee -- a prospective randomized clinical trial. | |
| | |
MedLine Citation:
|
PMID: 18430574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this independent prospective randomized trial, we compared the clinical effectiveness, functional outcome and patient satisfaction following intra articular injection with two viscosupplementation agents - Hylan G-F-20 (n=199) and Sodium Hyaluronate (n=193) in patients with osteoarthritis (OA) of the knee. All patients were prospectively reviewed by blinded independent assessors at pre injection, 6 weeks, 3, 6, 12 months. Knee pain and patient satisfaction were measured on a visual analogue scale. Functional outcome was assessed using WOMAC, Oxford knee score and EuroQol EQ-5D scores. Knee pain on VAS improved from 6.7 to 3.2 by 6 weeks (p=0.02) and was sustained until 12 months (3.7, p=0.04) with Hylan G-F 20. In the Sodium Hyaluronate group, pain improved from 6.6 to 5.7 at 6 weeks (p>0.05) and to 4.1 at 3 months (p=0.04) but was sustained only until 6 months (5.9, p>0.05). Improvement in the WOMAC pain subscale was significantly superior in the Hylan G-F 20 group at 3 months (p=0.02), 6 months (p=0.01) and 12 months (p=0.007). There was no significant difference in the EQ-5D scores at 6 weeks and 3 months between the two groups. The numbers of treatment related adverse events were higher (39 vs. 30) in the Hylan G-F 20 group. One patient in the Hylan G-F 20 group who had a serious adverse event was also included in the final analysis. Although both treatments offered significant pain reduction, it was achieved earlier and sustained for a longer period with Hylan G-F 20. From this study, it appeared that the clinical effectiveness and general patient satisfaction are better amongst patients who received Hylan G-F 20. |
| | |
Authors:
|
R Raman; A Dutta; N Day; H K Sharma; C J Shaw; G V Johnson |
Related Documents
:
|
15995414 - Development and early results of a new patellofemoral arthroplasty. 18004544 - The self-aligning knee prosthesis: clinical and radiological outcome and survival analy... 6692614 - Preliminary results with abrasion arthroplasty in the osteoarthritic knee. 20802414 - The application of biofeedback exercises in patients following arthroplasty of the knee... 18581284 - Effects of atorvastatin on progression-regression of renal injury in hyperlipidemic chi... 22993644 - Prognostication for body contouring surgery after bariatric surgery. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial Date: 2008-04-21 |
Journal Detail:
|
Title: The Knee Volume: 15 ISSN: 0968-0160 ISO Abbreviation: Knee Publication Date: 2008 Aug |
Date Detail:
|
Created Date: 2008-06-27 Completed Date: 2008-12-03 Revised Date: 2009-01-19 |
Medline Journal Info:
|
Nlm Unique ID: 9430798 Medline TA: Knee Country: England |
Other Details:
|
Languages: eng Pagination: 318-24 Citation Subset: IM |
Affiliation:
|
Department of Trauma and Orthopaedics, Hull Royal Infirmary, Hull, HU2 3JZ, United Kingdom. raghu1177@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biocompatible Materials
/
administration & dosage,
therapeutic use* Follow-Up Studies Humans Hyaluronic Acid / administration & dosage, analogs & derivatives*, therapeutic use* Middle Aged Osteoarthritis, Knee / drug therapy* Patient Satisfaction Prospective Studies Range of Motion, Articular Recovery of Function Treatment Outcome Viscosupplementation* |
| Chemical | |
Reg. No./Substance:
|
0/Biocompatible Materials; 125935-84-4/hylan; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: No carnitine palmitoyltransferase deficiency in skeletal muscle in 18 malignant hyperthermia suscept...
Next Document: Petiolins A-C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum.