Document Detail


Efficacy of Hylan G-F 20 and Sodium Hyaluronate in the treatment of osteoarthritis of the knee -- a prospective randomized clinical trial.
MedLine Citation:
PMID:  18430574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this independent prospective randomized trial, we compared the clinical effectiveness, functional outcome and patient satisfaction following intra articular injection with two viscosupplementation agents - Hylan G-F-20 (n=199) and Sodium Hyaluronate (n=193) in patients with osteoarthritis (OA) of the knee. All patients were prospectively reviewed by blinded independent assessors at pre injection, 6 weeks, 3, 6, 12 months. Knee pain and patient satisfaction were measured on a visual analogue scale. Functional outcome was assessed using WOMAC, Oxford knee score and EuroQol EQ-5D scores. Knee pain on VAS improved from 6.7 to 3.2 by 6 weeks (p=0.02) and was sustained until 12 months (3.7, p=0.04) with Hylan G-F 20. In the Sodium Hyaluronate group, pain improved from 6.6 to 5.7 at 6 weeks (p>0.05) and to 4.1 at 3 months (p=0.04) but was sustained only until 6 months (5.9, p>0.05). Improvement in the WOMAC pain subscale was significantly superior in the Hylan G-F 20 group at 3 months (p=0.02), 6 months (p=0.01) and 12 months (p=0.007). There was no significant difference in the EQ-5D scores at 6 weeks and 3 months between the two groups. The numbers of treatment related adverse events were higher (39 vs. 30) in the Hylan G-F 20 group. One patient in the Hylan G-F 20 group who had a serious adverse event was also included in the final analysis. Although both treatments offered significant pain reduction, it was achieved earlier and sustained for a longer period with Hylan G-F 20. From this study, it appeared that the clinical effectiveness and general patient satisfaction are better amongst patients who received Hylan G-F 20.
Authors:
R Raman; A Dutta; N Day; H K Sharma; C J Shaw; G V Johnson
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-04-21
Journal Detail:
Title:  The Knee     Volume:  15     ISSN:  0968-0160     ISO Abbreviation:  Knee     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-27     Completed Date:  2008-12-03     Revised Date:  2009-01-19    
Medline Journal Info:
Nlm Unique ID:  9430798     Medline TA:  Knee     Country:  England    
Other Details:
Languages:  eng     Pagination:  318-24     Citation Subset:  IM    
Affiliation:
Department of Trauma and Orthopaedics, Hull Royal Infirmary, Hull, HU2 3JZ, United Kingdom. raghu1177@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Biocompatible Materials / administration & dosage,  therapeutic use*
Follow-Up Studies
Humans
Hyaluronic Acid / administration & dosage,  analogs & derivatives*,  therapeutic use*
Middle Aged
Osteoarthritis, Knee / drug therapy*
Patient Satisfaction
Prospective Studies
Range of Motion, Articular
Recovery of Function
Treatment Outcome
Viscosupplementation*
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 125935-84-4/hylan; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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