| Efficacy of hydroxyurea in providing transfusion independence in β-thalassemia. | |
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MedLine Citation:
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PMID: 21602718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Packed red blood cell (PRC) transfusion with iron chelation is the mainstay of treatment for β-thalassemia major. This prospective interventional trial serves as a follow up to our similar earlier study that evaluated the efficacy and safety of hydroxyurea (HU) in minimizing PRC transfusions in patients with β-thalassemia major. METHODS: One hundred fifty-two patients with β-thalassemia major received HU at a mean dose of 16 mg/kg/d. The results were analyzed at the end of 24 months. Transfusion requirement during the 6 months preceding the study was considered as the control. RESULTS: One hundred forty-six of 152 patients were evaluated after 24 months of follow up; 6 patients were either lost to follow-up or withdrew consent. Grade 1 myelosuppression was observed in 4 patients and diarrhea in 2 patients. Sixty children (41%) did not require any transfusion after using HU; 57 patients (39%) showed partial response with greater than 50% reduction in PRC transfusion; and 29 patients (20%) were nonresponders with less than 50% reduction in PRC transfusion. The mean volume of PRC transfused was reduced for all patients. CONCLUSIONS: HU was found to be safe in patients with β-thalassemia major, and resulted in the reduction of transfusion requirement and in an increase in the interval between transfusions. |
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Authors:
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Saqib H Ansari; Tahir S Shamsi; Mushtaq Ashraf; Kousar Perveen; Tasneem Farzana; Muneera Bohray; Sajida Erum; Tabassum Mehboob |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 33 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-22 Completed Date: 2011-09-01 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 339-43 Citation Subset: IM |
Affiliation:
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Department of Pediatric Hematology, National Institute of Blood Diseases, Karachi, Pakistan. ansarisaqib@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Erythrocyte Transfusion / utilization* Female Follow-Up Studies Humans Hydroxyurea / administration & dosage*, adverse effects Infant Male Nucleic Acid Synthesis Inhibitors / administration & dosage*, adverse effects Treatment Outcome Young Adult beta-Thalassemia / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Nucleic Acid Synthesis Inhibitors; 127-07-1/Hydroxyurea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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