Document Detail


Efficacy of Epinastine Hydrochloride for Antigen-provoked Nasal Symptoms in Subjects with Orchard Grass Pollinosis.
MedLine Citation:
PMID:  21173568     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Among the gramineae species, orchard grass is a typical causative pollen that provokes seasonal rhinitis. The purpose of this study was to examine the protective efficacy of epinastine hydrochloride for signs and symptoms caused by repeated nasal provocation with discs containing orchard grass pollen. Methods: A single-dose, placebo-controlled, double-blind, crossover clinical study was conducted in subjects with orchard grass pollinosis. The pollen challenge was conducted with the use of provocation discs containing orchard grass pollen. Results: Epinastine hydrochloride suppressed nasal symptoms caused by nasal provocation tests using orchard grass pollen discs. Among the nasal symptoms, the number of sneezing was significantly inhibited 30 minutes and 60 minutes after the administration of epinastine hydrochloride, as compared with placebo. There were no adverse reactions to the study drugs. Conclusions: Our results suggest that nasal provocation tests with discs containing orchard grass pollen is a useful method for evaluating the onset of action of antiallergic drugs. As compared with placebo, epinastine hydrochloride decreased early-phase sneezing and the total nasal symptom score after repeated nasal provocations with orchard grass pollen discs.
Authors:
Minoru Gotoh; Kazuhiro Hashiguchi; Kimihiro Okubo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-25
Journal Detail:
Title:  Allergology international : official journal of the Japanese Society of Allergology     Volume:  60     ISSN:  1440-1592     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2010-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616296     Medline TA:  Allergol Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Otorhinolaryngology and Head/Neck Surgery, Nippon Medical School, Tokyo, Japan.
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