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Efficacy of Device-Guided Breathing for Hypertension in Blinded, Randomized, Active-Controlled Trials: A Meta-analysis of Individual Patient Data.
MedLine Citation:
PMID:  25222103     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Importance: Device-guided breathing (DGB) is recommended by the American Heart Association for its blood pressure-lowering effects. Most previous studies that showed beneficial effects on blood pressure had low methodological quality and only investigated short-term blood pressure effects.
Objective: To assess the efficacy of DGB on blood pressure in a meta-analysis of individual patient data from blinded, randomized controlled trials with an active control group.
Data Sources: MEDLINE, EMBASE, clinicaltrials.gov, and the Cochrane Library.
Study Selection: Included were randomized studies of at least 4 weeks' duration, with a single- or double-blind design and an active control group. Bias was assessed with the Cochrane risk of bias tool, and analyses were performed with linear mixed models.
Data Extraction and Synthesis: Articles were searched in MEDLINE (using PubMed), EMBASE, and the Cochrane Library.
Main Outcomes and Measures: Office blood pressure.
Results: From the 15 selected abstracts, 5 studies were suitable for inclusion. Individual patient data from 2 of 5 studies were not provided. The effect of DGB on office systolic blood pressure compared with music therapy or a sham device was 2.2 mm Hg (95% CI, -2.7 to 7.0) in favor of the control group; DGB did not significantly lower office diastolic blood pressure (0.2 mm Hg [95% CI, -2.8 to 3.1] in favor of DGB).
Conclusions and Relevance: All trials included in the analysis had a short follow-up period; therefore, no recommendations could be made regarding hypertension treatment. Treatment with DGB did not significantly lower office blood pressure compared with a sham procedure or music therapy.
Authors:
Gijs W D Landman; Kornelis J J van Hateren; Peter R van Dijk; Susan J J Logtenberg; Sebastiaan T Houweling; Klaas H Groenier; Henk J G Bilo; Nanne Kleefstra
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-15
Journal Detail:
Title:  JAMA internal medicine     Volume:  -     ISSN:  2168-6114     ISO Abbreviation:  JAMA Intern Med     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101589534     Medline TA:  JAMA Intern Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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