| Efficacy of Anti-Interleukin-1 Receptor Antagonist Anakinra (Kineret®) in a Case of Refractory Sweet's Syndrome. | |
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MedLine Citation:
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PMID: 21464561 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Sweet's syndrome is a neutrophilic dermatosis characterized by fever, an elevated neutrophil count, and painful erythematous cutaneous lesions. Histopathological analysis reveals a neutrophilic dermal infiltrate. Systemic corticosteroid therapy remains the mainstay of treatment. We report the case of a 66-year-old male patient who had a 5-year history of Sweet's syndrome refractory to various conventional treatments. Anti-interleukin-1 receptor antagonist anakinra was initiated and this resulted in a dramatic clinical and biological improvement. Anakinra is a promising treatment for neutrophilic dermatoses and sheds light on the interleukin-1/inflammasome pathway as central in the physiopathology of neutrophilic dermatosis. |
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Authors:
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Nicolas Kluger; Déborah Gil-Bistes; Bernard Guillot; Didier Bessis |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-05 |
Journal Detail:
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Title: Dermatology (Basel, Switzerland) Volume: - ISSN: 1421-9832 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203244 Medline TA: Dermatology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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Service de Dermatologie, Hôpital Saint-Eloi, CHU de Montpellier, Université Montpellier I, Montpellier, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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