| Efficacy of Aliskiren in Japanese Chronic Kidney Disease Patients with Hypertension. | |
| | |
MedLine Citation:
|
PMID: 22260457 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Aliskiren, a novel direct renin inhibitor, is hypothesized to inhibit the renin-angiotensin- system. This study attempted to provide insight into this mechanism by examining the antihypertensive and renoprotective effects of aliskiren in hypertensive chronic kidney disease (CKD) patients. Methods: After recruitment, 43 hypertensive CKD patients (mean age, 53.7 years) began treatment of aliskiren. The patients were classified into high (over 30 mL/min/1.73 m(2)) estimated glomerular filtration rate (eGFR) group or low (under 30 mL/min/1.73 m(2)) eGFR group for comparison of measurements of various parameters over the 6-month observation period. Results: Systolic blood pressure/diastolic blood pressure of 150 mg/day group decreased to an average of 126.8 ± 21.6 mmHg/69.3 ± 15.1 mmHg (average decrease: -7.4/-8.3 mmHg) over the 6-month observation period, while that of 300 mg/day group significantly decreased to an average of 133.5 ± 14.0 mmHg/71.5 ± 11.7 mmHg (average decrease: -21.1/-14.6 mmHg). Urinary protein of all patients decreased slightly and insignificantly to 1.1 ± 1.7 g/gCr from 1.4 ± 2.5 g/gCr. The serum creatinine (Cr) level of all patients decreased from 1.81 ± 1.10 mg/dL to 1.78 ± 0.82 mg/dL. Although the serum Cr level of the high eGFR group decreased from 1.28 ± 0.45 mg/dL to 1.27 ± 0.57 mg/dL, that of the low eGFR group slightly but insignificantly increased from 2.49 ± 0.64 mg/dL to 2.69 ± 1.11 mg/dL. Conclusion: Administration of aliskiren exerts an antihypertensive effect on hypertensive CKD patients that may lead to a decrease in urinary protein and an improvement in renal functioning. |
| | |
Authors:
|
Yukinao Sakai; Tomoyuki Otsuka; Dai Ohno; Tsuneo Murasawa; Naoki Sato; Kyoichi Mizuno |
Related Documents
:
|
1777957 - Total body blood volume redistribution in porcine e. coli septic shock: effect of volum... 21824997 - High-pressure plastic injection injury of the hand: case report. 22117907 - Hypertension management in an outpatient clinic at the institute of cardiology of abidj... 12760977 - Acute intravascular volume expansion with rapidly administered crystalloid or colloid i... 8586817 - Lack of correlation between microalbuminuria and endothelial function in essential hype... 17748937 - First natural occurrence of coesite. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-20 |
Journal Detail:
|
Title: Renal failure Volume: - ISSN: 1525-6049 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Nephrology, Department of Internal Medicine, Nippon Medical School Musashikosugi Hospital , Kawasaki , Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The importance of the cell membrane on the mechanism of action of cyclotides.
Next Document: Airway management of recovered pediatric patients with severe head and neck burns: a review.