Document Detail

Efficacy of 7-day treatment with metronidazole+miconazole (Neo-Penotran) - a triple-active pessary for the treatment of single and mixed vaginal infections.
MedLine Citation:
PMID:  11430939     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the efficacy of Neo-Penotran pessaries (metronidazole 500 mg + miconazole nitrate 100 mg) in candidal, bacterial and trichomonal vaginitis and in mixed vaginal infections. METHOD: Ninety-seven patients with clinical diagnosis of vaginitis entered this open, non-comparative study. Each patient inserted one pessary twice daily for 7 days. Gynecological and microbiological assessments were carried out before, and 8-10/21-23 days after the start of treatment. RESULTS: Vaginitis symptoms were resolved in 91% of the 74 patients evaluated, and improved in a further 7%. Microbiological cure rates were 97.3% for trichomonal, 86.6% for bacterial and 81% for candidal vaginitis. Recurrence rates were 2.7, 3.8 and 16.1%, respectively. Overall microbiological cure rate for mixed infections was 86%, with 93% for trichomonal+bacterial, and 73% for bacterial+candidal vaginitis. In two out of three cases with trichomonal+bacterial+candidal infection, the microorganisms were eradicated completely. CONCLUSION: Neo-Penotran provides immediate and effective treatment for vaginitis, irrespective of single or multiple infection, even when the diagnosis may be uncertain.
E Ozyurt; M B Toykuliyeva; I L Danilyans; O Morton; G Baktir
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  74     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-06-29     Completed Date:  2001-09-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  35-43     Citation Subset:  IM    
Onur Medical Research Ltd., Istanbul, Turkey.
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MeSH Terms
Administration, Intravaginal
Antifungal Agents / administration & dosage*
Antitrichomonal Agents / administration & dosage*
Candidiasis, Vulvovaginal / drug therapy
Drug Administration Schedule
Drug Therapy, Combination
Metronidazole / administration & dosage*
Miconazole / administration & dosage*
Middle Aged
Treatment Outcome
Trichomonas Vaginitis / drug therapy
Vaginitis / drug therapy*
Vaginosis, Bacterial / drug therapy
Reg. No./Substance:
0/Antifungal Agents; 0/Antitrichomonal Agents; 22916-47-8/Miconazole; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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