| Efficacy of 4-methylpyrazole in ethylene glycol poisoning: clinical and toxicokinetic aspects. | |
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MedLine Citation:
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PMID: 8198831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Potentially fatal ethylene glycol intoxication in an adult with normal renal function was treated with 4-methylpyrazole administered three hours after the incident occurred. The plasma ethylene glycol concentration was 3.5 g l-1 on admission. The metabolic acidosis present on admission resolved within four hours, and the subsequent clinical course was uneventful. The apparent plasma half-life of ethylene glycol was 16 h and the mean renal and plasma clearances of ethylene glycol were 24 and 25 ml min-1, respectively. These results support the hypothesis that complete blockade of hepatic metabolism of ethylene glycol is achieved by 4-methylpyrazole. The only side-effect observed as a result of treatment was a transient slight increase in serum transaminase activity. |
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Authors:
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P Harry; A Turcant; G Bouachour; P Houze; P Alquier; P Allain |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Human & experimental toxicology Volume: 13 ISSN: 0960-3271 ISO Abbreviation: Hum Exp Toxicol Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-07-05 Completed Date: 1994-07-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9004560 Medline TA: Hum Exp Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 61-4 Citation Subset: IM |
Affiliation:
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Centre Anti-Poisons-Réanimation Médicale, CHU, Angers, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ethylene Glycol Ethylene Glycols / blood, poisoning* Humans Male Poisoning / drug therapy Pyrazoles / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Ethylene Glycols; 0/Pyrazoles; 107-21-1/Ethylene Glycol; 7554-65-6/fomepizole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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