Document Detail

Efficacy of 3 different steroid treatments for sudden sensorineural hearing loss: a prospective, randomized trial.
MedLine Citation:
PMID:  23077155     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We treated patients with idiopathic sudden sensorineural hearing loss (ISSNHL) with several protocols on an outpatient department (OPD) basis. The study compared the efficacy of 3 different steroid treatments for ISSNHL.
STUDY DESIGN: A prospective randomized controlled study.
SETTING: Tertiary referral center.
METHODS: A total of 60 patients diagnosed with ISSNHL were treated through OPD. They were randomly and equally divided into 3 groups based on therapy: oral steroid for 10 days (group I), intratympanic dexamethasone injection (ITDI) 4 times (group II), and both (group III). Pure-tone average (PTA) was measured by taking 4 frequencies (0.5, 1, 2, and 3 kHz). Hearing change was evaluated by comparing pre- and posttreatment PTAs. Recovery rate was assessed by American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) Clinical Practice Guidelines.
RESULTS: The hearing gain was 12.8 ± 15.4 decibels (dB) in group I, 12.1 ± 14.6 dB in group II, and 21.9 ± 26.2 dB in group III. The recovery rate was 60% in groups I and III and 55% in group II. The overall recovery rate was 58.3% (35 of 60 patients). There was no significant difference in hearing gain and recovery rates for the 3 groups. Frequency-specific hearing gain also did not differ significantly among groups.
CONCLUSION: Three different treatment protocols (oral steroid, ITDI, or the combination) resulted in similar hearing recovery rates. Therefore, OPD-based systemic and/or local steroid therapy can be recommended as an initial treatment in ISSNHL.
Hye Jin Lim; Yun Tae Kim; Seong Jun Choi; Jong Bin Lee; Hun Yi Park; Keehyun Park; Yun-Hoon Choung
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2012-10-16
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  148     ISSN:  1097-6817     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-02-27     Revised Date:  2013-07-05    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  121-7     Citation Subset:  IM    
Department of Otolaryngology, Ajou University School of Medicine, Suwon, Republic of Korea.
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MeSH Terms
Administration, Oral
Aged, 80 and over
Ambulatory Care / methods
Audiometry, Pure-Tone
Dexamethasone / administration & dosage*
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Follow-Up Studies
Hearing Loss, Sensorineural / diagnosis,  drug therapy*
Hearing Loss, Sudden / diagnosis,  drug therapy*
Injections, Intralesional
Middle Aged
Prednisolone / administration & dosage*
Prospective Studies
Recovery of Function
Reference Values
Severity of Illness Index
Tertiary Care Centers
Treatment Outcome
Tympanic Membrane / drug effects
Young Adult
Reg. No./Substance:
50-02-2/Dexamethasone; 50-24-8/Prednisolone
Comment In:
Otolaryngol Head Neck Surg. 2013 Jun;148(6):1063   [PMID:  23690085 ]
Otolaryngol Head Neck Surg. 2013 Jun;148(6):1062   [PMID:  23690084 ]
Erratum In:
Otolaryngol Head Neck Surg. 2013 Jun;148(6):1064

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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