Document Detail

Efficacy of 17alpha-hydroxyprogesterone caproate in the prevention of premature labor.
MedLine Citation:
PMID:  1099445     Owner:  NLM     Status:  MEDLINE    
We conducted a double-blind study to determine the efficacy of 17alpha-hydroxyprogesterone caproate in preventing premature delivery in 43 high-risk patients. Premature delivery did not occur in 18 patients receiving the progestational agent, whereas 41 per cent of the 22 receiving the palcebo had premature delivery (P less than 0.01). The mean duration of pregnancy and the mean birth weight in the former group (38.6 weeks +/- 1.6 S.D., and 2836 g +/- 412 S.D.) were both significantly greater (P less than 0.025) than that in the latter (35.2 weeks +/- 6.7 S.D.; 2361 g +/- 1085 S.D.). The perinatal mortality rate in the group given the progestational agent (O per cent) was significantly less than that observed in the placebo group (27 per cent) (P less than 0.05). Although there were no complications attributable to the progestational drug, the study population was too small for assessment of immediate or long term safety. However, the results indicate a possible obstetric use for this drug.
J W Johnson; K L Austin; G S Jones; G H Davis; T M King
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  293     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1975-11-20     Completed Date:  1975-11-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  675-80     Citation Subset:  AIM; IM    
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MeSH Terms
Cervix Uteri / surgery
Clinical Trials as Topic
Fetal Death / epidemiology
Hydroxyprogesterones / analysis*,  therapeutic use
Infant Mortality
Infant, Newborn
Obstetric Labor, Premature / prevention & control*,  surgery
Pregnanediol / urine
Time Factors
Reg. No./Substance:
0/Hydroxyprogesterones; 26445-07-8/Pregnanediol
Comment In:
N Engl J Med. 2003 Jun 12;348(24):2453-5   [PMID:  12802032 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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