Document Detail

[Efficacy of 153Sm-EDTMP in the treatment of prostate cancer with bone metastasis].
MedLine Citation:
PMID:  23214246     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To investigate the efficacy of 153Sm-EDTMP in the treatment of bone metastasis of prostate cancer (PCa) by comparison with zoledronic acid.
METHODS: We assigned 55 PCa patients with bone metastasis to receive 153Sm-EDTMP (n = 31) and zoledronic acid (n = 24), the former injected intravenously at the dose of 37.0 MBq/kg body weight, and the latter administered by slow intravenous drip at 4 mg in 100 ml of 0.9% sodium chloride. We performed 99mTc-MDP bone scan before and 1 -2 months after the treatment.
RESULTS: The rate of pain relief was 83.9% in the 153Sm-EDTMP group and 58.3% in the zoledronic acid group (P = 0.035), and that of bone metabolism change was 64.5% in the former and 33.3% in the latter (P = 0.022).
CONCLUSION: 153Sm-EDTMP is an ideal agent for the treatment of prostate cancer with bone metastasis.
Juan-Yi Feng; Chuang-Qi Wu; Peng Zhang; She-Jiao Wang; Xiang-Hong Zheng
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Zhonghua nan ke xue = National journal of andrology     Volume:  18     ISSN:  1009-3591     ISO Abbreviation:  Zhonghua Nan Ke Xue     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101093592     Medline TA:  Zhonghua Nan Ke Xue     Country:  China    
Other Details:
Languages:  chi     Pagination:  982-5     Citation Subset:  IM    
Department of Nuclear Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an, Shaanxi 710004, China.
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