Document Detail

Effects of high-intensity exercise and protein supplement on muscle mass in ADL dependent older people with and without malnutrition: a randomized controlled trial.
MedLine Citation:
PMID:  21808934     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Loss of muscle mass is common among old people living in institutions but trials that evaluate interventions aimed at increasing the muscle mass are lacking. Objective, participants and intervention: This randomized controlled trial was performed to evaluate the effect of a high-intensity functional exercise program and a timed protein-enriched drink on muscle mass in 177 people aged 65 to 99 with severe physical or cognitive impairments, and living in residential care facilities.
DESIGN: Three-month high-intensity exercise was compared with a control activity and a protein-enriched drink was compared with a placebo drink. A bioelectrical impedance spectrometer (BIS) was used in the evaluation. The amount of muscle mass and body weight (BW) were followed-up at three and six months and analyzed in a 2 x 2 factorial ANCOVA, using the intention to treat principle, and controlling for baseline values.
RESULTS: At 3-month follow-up there were no differences in muscle mass and BW between the exercise and the control group or between the protein and the placebo group. No interaction effects were seen between the exercise and nutritional intervention. Long-term negative effects on muscle mass and BW was seen in the exercise group at the 6-month follow-up.
CONCLUSION: A three month high-intensity functional exercise program did not increase the amount of muscle mass and an intake of a protein-enriched drink immediately after the exercise did not induce any additional effect on muscle mass. There were negative long-term effects on muscle mass and BW, indicating that it is probably necessary to compensate for an increased energy demand when offering a high-intensity exercise program.
M Carlsson; H Littbrand; Y Gustafson; L Lundin-Olsson; N Lindelöf; E Rosendahl; L Håglin
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of nutrition, health & aging     Volume:  15     ISSN:  1760-4788     ISO Abbreviation:  J Nutr Health Aging     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-02     Completed Date:  2012-02-07     Revised Date:  2012-12-17    
Medline Journal Info:
Nlm Unique ID:  100893366     Medline TA:  J Nutr Health Aging     Country:  France    
Other Details:
Languages:  eng     Pagination:  554-60     Citation Subset:  IM    
Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umea University, Sweden.
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MeSH Terms
Activities of Daily Living
Aged, 80 and over
Analysis of Variance
Body Weight*
Dietary Proteins / pharmacology*
Dietary Supplements
Disabled Persons
Exercise Therapy* / adverse effects
Follow-Up Studies
Housing for the Elderly
Intention to Treat Analysis
Muscle, Skeletal / drug effects,  pathology*
Physical Exertion
Sarcopenia / prevention & control*
Reg. No./Substance:
0/Dietary Proteins
Comment In:
J Nutr Health Aging. 2012 Aug;16(8):736   [PMID:  23076518 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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