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Effervescent redispersion of lyophilized polymeric nanoparticles.
MedLine Citation:
PMID:  23343158     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Freeze-drying is an attractive method for converting nanoparticulate pharmaceutical dispersions into a stable form with a long shelf life. However, practical challenges in translating laboratory practice to the clinic, such as high protectant osmolarity and infeasible reconstitution methods, currently limit lyophilized formulation development of nanoparticle therapeutics. Results: We demonstrate the use of effervescent redispersion for the reconstitution of lyophilized polymeric nanoparticles and we show that a 3:1 mass ratio of effervescent salt produced the optimum redispersibility. With only low-energy hand agitation, reconstitution to sizes less than 600 nm was achieved. Second, the effect of nanoparticle formulation parameters (dispersion concentration, molecular weight of the stabilizing polymer, and physical state of the nanoparticle core) on particle redispersibility were examined. Conclusion: This novel freeze-drying and reconstitution method offers a route to producing redispersible dry powders of nanoparticle therapeutics.
Authors:
Carlos E Figueroa; Douglas H Adamson; Robert K Prud'homme
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic delivery     Volume:  4     ISSN:  2041-5990     ISO Abbreviation:  Ther Deliv     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101538870     Medline TA:  Ther Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  177-90     Citation Subset:  IM    
Affiliation:
Department of Chemical & Biological Engineering, Princeton University, Princeton, NJ 08544, USA.
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