Document Detail


Effervescent paracetamol poisoning: a case report.
MedLine Citation:
PMID:  12501034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Severe poisoning with effervescent paracetamol tablets has never been described in the literature. Indeed, the effervescent formulation contains high amounts of sodium and bicarbonate, both responsible for important emetic properties in the case of massive ingestion. Moreover, dissolving more than 6-8 tablets in the same glass appears to be difficult. We report a well-documented case of a patient with potentially hepatotoxic serum levels after the ingestion of 16 g effervescent paracetamol, apparently without vomiting. We show that the difficulties of a massive oral intake may be overcome by a slow intake. Nevertheless, this case report does not modify the important assertion that effervescent paracetamol use could limit the risk of life-threatening intoxication by a single massive acute overdose.
Authors:
Franck Verschuren; Frédéric Thys; Xavier Wittebole; Paul Janssens; Abdulwalhed Elgariani; Eric Marion; Philippe Meert; Pierre Wallemacq; Philippe Hantson; Marc Reynaert
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of emergency medicine : official journal of the European Society for Emergency Medicine     Volume:  9     ISSN:  0969-9546     ISO Abbreviation:  Eur J Emerg Med     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-25     Completed Date:  2003-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9442482     Medline TA:  Eur J Emerg Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  339-41     Citation Subset:  IM    
Affiliation:
Service des Urgences, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, B-1200 Brussels, Belgium. franck.verschuren@yucom.be
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / blood,  pharmacokinetics,  poisoning*
Acetylcysteine / therapeutic use
Adult
Analgesics, Non-Narcotic / blood,  pharmacokinetics,  poisoning*
Ethanol / administration & dosage,  blood
Half-Life
Humans
Male
Suicide, Attempted*
Chemical
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen; 616-91-1/Acetylcysteine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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