| Efferent limb of the coronary vasoconstrictor reflex elicited by distension of the descending colon in anesthetized dogs. | |
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MedLine Citation:
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PMID: 1554869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Distension of the descending colon elicits reflex coronary vasoconstriction. To study the efferent branch of this reflex, experiments were performed on 5 dogs anesthetized with pentobarbitone. A pouch was formed from the distal 15 cm of the descending colon and distended at constant pressure (54 +/- 8.9 mmHg) with warm Ringer solution from a pressurized bottle. During distensions of the colon, arterial blood pressure and heart rate were kept constant by the withdrawal of blood and pacing of the heart, respectively. Experiments were performed before and after intravenous bretylium tosylate (10 mg/kg), a compound which prevents the outflow of catecholamines from the sympathetic postganglionic neurons. Before chemical sympathectomy, colon distension at constant heart rate and blood pressure caused a decrease in mean coronary blood flow by 7 +/- 3.3% (mean +/- SD, p less than 0.0005). This response was abolished after the administration of bretylium (-0.07 +/- 0.95%, p greater than 0.40). We conclude that the efferent branch of the reflex coronary vasoconstriction elicited by colon distension is through sympathetic nerves. |
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Authors:
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A Cevese; D A Mary; R Poltronieri; F Schena; G Vacca |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardioscience Volume: 3 ISSN: 1015-5007 ISO Abbreviation: Cardioscience Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-05-07 Completed Date: 1992-05-07 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9014943 Medline TA: Cardioscience Country: ITALY |
Other Details:
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Languages: eng Pagination: 35-40 Citation Subset: IM |
Affiliation:
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Institute of Human Physiology, Verona, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colon / innervation* Coronary Circulation / physiology Coronary Vessels / innervation*, physiology Dogs Efferent Pathways / anatomy & histology, physiology Pentobarbital Pressure Reflex / physiology* Sympathetic Nervous System / anatomy & histology, physiology* Vasoconstriction / physiology* |
| Chemical | |
Reg. No./Substance:
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76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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