| Efferent and afferent vagal actions on cortical blood flow and kainic acid-induced seizure activity in urethane anesthetized rats. | |
| | |
MedLine Citation:
|
PMID: 20510656 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Autonomic dysfunction during seizures can induce bradyarrhythmia via efferent vagal overactivity. We studied cardiovascular, brain blood flow, and electroencephalographic consequences of vagal stimulation during seizures in rats. Efferent vagal stimulation reduced seizure activity, completely suppressing it at high frequencies, by reducing heart rate, arterial pressure, and cortical blood flow. Afferent vagal activation was more variable, and the highest stimulation frequencies also appeared to reduce cortical blood flow. We conclude that efferent vagal activity can arrest ongoing seizure activity by ultimately decreasing hippocampal blood flow. Afferent vagal activity (which does not occur during seizures) may have a similar action. |
| | |
Authors:
|
Harumi Hotta; Nobuhiro Watanabe; Rena Orman; Mark Stewart |
Related Documents
:
|
19304946 - Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels. 21316046 - Contrast-enhanced ultrasound reveals real-time spatial changes in vascular perfusion du... 10474076 - The effects of high-dose corticosteroid therapy on optic nerve head blood flow in exper... 1115846 - Effect of vagus nerve stimulation on coagulability of the blood in cats. 8255146 - Effect of peritoneal and gastric irrigation with ozonated saline on arterial and venous... 3066416 - Pharmacokinetics of 14c-etretinate in healthy volunteers and two patients with biliary ... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-26 |
Journal Detail:
|
Title: Autonomic neuroscience : basic & clinical Volume: 156 ISSN: 1872-7484 ISO Abbreviation: Auton Neurosci Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-08-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100909359 Medline TA: Auton Neurosci Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 144-8 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of the Autonomic Nervous System, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acetylcholine as an age-dependent non-neuronal source in the heart.
Next Document: Report of two patients with associated conditions in addition to cystic fibrosis.