Document Detail

Effects of zinc gluconate and 2 other divalent cationic compounds on olfactory function in mice.
MedLine Citation:
PMID:  22330252     Owner:  NLM     Status:  MEDLINE    
Intranasal application of zinc gluconate has commonly been used to treat the common cold. The safety of this treatment, however, has come into question recently. In addition to a United States recall of a homeopathic product that contains zinc gluconate, abundant literature reports cytotoxic effects of zinc on the olfactory epithelium. Additional research suggests that divalent cations (such as zinc) can block ion channels that facilitate the transduction of odors into electrical signals on the olfactory epithelium. The purpose of the current study was 2-fold: to confirm whether zinc gluconate causes anosmia and to reveal whether any other divalent cationic compounds produce a similar effect. Groups of mice underwent a buried food-pellet test to gauge olfactory function and then were nasally irrigated with 1 of 3 divalent cationic compounds. When tested after treatment, mice irrigated with zinc gluconate and copper gluconate experienced a marked increase in food-finding time, indicating that they had lost their ability to smell a hidden food source. Control mice irrigated with saline had a significantly lower increase in times. These results confirm that zinc gluconate can cause anosmia and reveal that multiple divalent cations can negatively affect olfaction.
Christopher A Duncan-Lewis; Roy L Lukman; Robert K Banks
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comparative medicine     Volume:  61     ISSN:  1532-0820     ISO Abbreviation:  Comp. Med.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2012-02-14     Completed Date:  2012-06-18     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100900466     Medline TA:  Comp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-5     Citation Subset:  IM    
Office of Research and Commercialization, University of Central Florida, Orlando, Florida, USA.
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MeSH Terms
Administration, Intranasal
Analysis of Variance
Appetitive Behavior / drug effects
Gluconates / administration & dosage,  adverse effects,  toxicity*
Olfaction Disorders / chemically induced*
Time Factors
Reg. No./Substance:
0/Gluconates; R4R8J0Q44B/gluconic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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