Document Detail

Effects of zinc, copper, and selenium on placental cadmium transport.
MedLine Citation:
PMID:  15621926     Owner:  NLM     Status:  MEDLINE    
The objective of the present study was to evaluate the potential effects of zinc, copper, and selenium on placental cadmium transport. From November 2002 through January 2003, a total of 47 healthy pregnant women from Da-Ye City, Hubei Province in Central China participated in the study. Their age, parity, gestational age, pregnancy history, and lifestyle data were obtained by questionnaire interview. The placental, whole-blood, and cord blood levels of cadmium were determined by inductively coupled plasma mass spectrometer (ICP-MS), whole-blood zinc was measured by flame atomic absorption spectrometry (F-AAS), whole-blood copper by ICP-MS, and selenium was by atomic fluorescence spectrophotometry (AFS). The cord blood cadmium concentration (0.020-1.48 microg/L) was significantly lower than in maternal blood (0.80-25.20 microg/L, p<0.01). The placental cadmium concentration was from 0.082 to 3.97 microg/g dry weight. Multiple linear regression analysis indicated that lower levels of maternal blood copper were significantly associated with higher cadmium concentrations in cord blood. Placental cadmium in women with lower levels of maternal blood zinc was significantly higher than in those with normal zinc levels. The placental cadmium level in women with lower whole-blood selenium was significantly lower than in subjects with normal selenium levels. It was concluded that the essential elements copper, selenium, and zinc might significantly affect placental cadmium transport.
Yali Zhang; Yongcheng Zhao; Jixian Wang; Hongda Zhu; Qingfen Liu; Yaguang Fan; Naifen Wang; Aiping Liu; Husheng Liu; Li Ou-Yang; Jinhui Zhao; Tiqiang Fan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  102     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2004  
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-49     Citation Subset:  IM    
Department of Biology, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, P. O. Box 71, 300192 Tianjin, People's Republic of China.
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MeSH Terms
Biological Transport
Cadmium / blood,  metabolism*
Copper / blood*
Fetal Blood / chemistry
Nutritional Status
Placenta / metabolism*
Reference Values
Regression Analysis
Selenium / blood*
Zinc / blood*
Reg. No./Substance:
7440-43-9/Cadmium; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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