Document Detail

Effects of xenobiotics and nutrients on host resistance studied in experimental human infections adapted to rodents.
MedLine Citation:
PMID:  18765286     Owner:  NLM     Status:  MEDLINE    
Interactions among infectious agents, nutrients and xenobiotics in which, xenobiotics and nutrients may affect host resistance to infection, as well as the microorganism virulence are a developing concern in food and environmental safety assessment. Nutrients and xenobiotics may induce either immunostimulative or immunosuppressive effects that may affect the host resistance and the course of the disease differently in different infections. This field has become a new avenue of research in food toxicology and food-borne diseases. For this purpose, some host resistance models in rodents are available but more are needed. Several microorganisms produce a clinically relevant disease useful for estimation of risk to man. Previously and currently used models include bacterial, viral and parasitic infections. The used microorganisms are either human pathogens adapted to experimental animals or unadapted human pathogens for which adequate animal models exist, where host resistance mechanisms and pathophysiological changes in animal and man are comparable. This report is a summary of effects of xenobiotics and nutrients on host resistance in presently used experimental human infections adapted to rodents.
Nils-Gunnar Ilbäck; Peter Frisk; Göran Friman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-08-13
Journal Detail:
Title:  Journal of pharmacological and toxicological methods     Volume:  58     ISSN:  1873-488X     ISO Abbreviation:  J Pharmacol Toxicol Methods     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-10     Completed Date:  2009-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206091     Medline TA:  J Pharmacol Toxicol Methods     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-88     Citation Subset:  IM    
Infectious Diseases, Department of Medical Sciences, Uppsala University Hospital, Sweden; Toxicology Division, National Food Administration, Uppsala, Sweden.
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MeSH Terms
Disease Models, Animal
Host-Pathogen Interactions
Immunity, Innate / drug effects*
Infection / microbiology*
Rodentia / microbiology
Xenobiotics / pharmacology*
Reg. No./Substance:

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