Document Detail


Effects of winter birth season and prenatal cockroach and mouse allergen exposure on indoor allergen-specific cord blood mononuclear cell proliferation and cytokine production.
MedLine Citation:
PMID:  18727476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Season of birth has been associated with the development of atopy and asthma. Relationships among a particular birth season, maternal allergen exposure during the birth season, and childhood development of allergies to allergens in higher concentration during the birth season may be important.
OBJECTIVE: To investigate the effects of winter birth (January 1 to March 31) and prenatal cockroach and mouse allergens in settled dust on indoor allergen-specific cord blood mononuclear cell (CBMC) proliferation, TH2 production, and cord blood IgE concentration.
METHODS: As part of an ongoing prospective study, 350 cord blood samples were collected. The CBMCs were cultured with cockroach, dust mite, and mouse protein extracts, and proliferation was measured. Interleukin 5, interferon-delta, and total IgE levels were measured. Home dust samples were analyzed for cockroach and mouse allergens.
RESULTS: An isolated association was observed between winter birth and a greater mean (SD) cockroach interleukin 5 ratio (winter vs nonwinter birth: 26,043 [11,403] vs 11,344 [3,701]; P = .02). Other associations between winter birth and increased CBMC proliferation, T-helper cytokines, or cord blood IgE levels were not detected. Higher mouse allergen levels were associated with decreased mouse-induced proliferation (winter vs nonwinter birth: mean [SD] stimulation index, 1.72 [0.12] vs 2.02 [0.11]; P = .04).
CONCLUSIONS: Winter birth and increased cockroach or mouse allergen levels during pregnancy were not consistently associated with greater CBMC proliferation, T-helper cytokine production, or cord blood IgE levels. Greater indoor allergen exposure during pregnancy does not seem to affect the development of cockroach or mouse immune responses in utero.
Authors:
Cynthia Lendor; Alina Johnson; Matthew Perzanowski; Ginger L Chew; Inge F Goldstein; Elizabeth Kelvin; Frederica Perera; Rachel L Miller
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  101     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-27     Completed Date:  2008-09-22     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Columbia University, New York, New York 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology*
Animals
Cell Proliferation
Cockroaches / immunology*
Cohort Studies
Environmental Exposure / adverse effects
Female
Fetal Blood / immunology
Humans
Immunoglobulin E / blood
Interferon-gamma / blood*
Interleukin-5 / blood*
Leukocytes, Mononuclear / immunology*,  metabolism
Longitudinal Studies
Male
Mice
Parturition
Pregnancy
Pyroglyphidae / immunology
Seasons
Th2 Cells / immunology*,  metabolism
Grant Support
ID/Acronym/Agency:
M01 RR000645-320895/RR/NCRR NIH HHS; P01 ES009600/ES/NIEHS NIH HHS; P01 ES009600-090005/ES/NIEHS NIH HHS; P01 ES09600/ES/NIEHS NIH HHS; P30 ES009089/ES/NIEHS NIH HHS; P30 ES009089-049001/ES/NIEHS NIH HHS; R01 ES008977-11/ES/NIEHS NIH HHS; R01 ES013163-01A1/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 0/IL5 protein, human; 0/Interleukin-5; 37341-29-0/Immunoglobulin E; 82115-62-6/Interferon-gamma
Comments/Corrections

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