Document Detail

Effects of the whole-body cryotherapy on a total antioxidative status and activities of some antioxidative enzymes in blood of patients with multiple sclerosis-preliminary study.
MedLine Citation:
PMID:  20299758     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: There is evidence that multiple sclerosis (MS) is not only characterized by immune mediated inflammatory reactions but also by neurodegenerative processes. Neutralization of oxidative stress and excitotoxicity, might represent a therapeutic approach to provide neuroprotection in MS. The purpose of this study was to compare changes in total antioxidative status and activities of chosen antioxidative enzymes, such as: SOD, CAT in erythrocytes of patients with MS before and after using WBCT with control group. MATERIALS AND METHODS: 32 patients with multiple sclerosis (ICD10-G35) and 20 healthy subjects were recruited for the study. The examined MS group (n=16) was treated with a series of 10 daily exposures in a cryogenic chamber (2-3 min, from -120 degrees C to -110 degrees C) and program of exercises. The control MS group (n=16) had only exercises. Plasma TAS as well as SOD and CAT activities in erythrocytes were measured. RESULTS: The level of TAS in MS patients was distinctly reduced compared to healthy subjects. After two weeks of WBCT treatment an increase of TAS in the whole examined group (p>0.01) were observed in relation to control MS group. There was not increase of CuZnSOD and CAT activities. CONCLUSION: Our results suggest positive antioxidant effects of WBCT as a short-term adjuvant treatment for patients suffered due to MS.
Elzbieta Miller; Ma?gorzata Mrowicka; Katarzyna Malinowska; Krystian Zo?y?ski; J?zef Kedziora
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of medical investigation : JMI     Volume:  57     ISSN:  1349-6867     ISO Abbreviation:  J. Med. Invest.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-19     Completed Date:  2010-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716841     Medline TA:  J Med Invest     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  168-73     Citation Subset:  IM    
Rehabilitation Ward, III General Hospital in L?dz, Poland.
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MeSH Terms
Antioxidants / metabolism*
Catalase / blood
Multiple Sclerosis / metabolism,  therapy*
Superoxide Dismutase / blood
Reg. No./Substance:
0/Antioxidants; EC; EC Dismutase

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