Document Detail

Effects of whey peptides on cardiovascular disease risk factors.
MedLine Citation:
PMID:  17086017     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that peptides derived from milk proteins can improve blood pressure. Therefore, the authors tested the blood pressure-lowering effects of a hydrolyzed whey protein supplement rich in bioactive peptides. In a 6-week controlled study, 30 prehypertensive or stage 1 hypertensive subjects (blood pressure >or=120/80 mm Hg and <or=155/95 mm Hg) were randomized to receive 20 g/d of either a hydrolyzed whey protein (active treatment) or an unmodified whey protein (control treatment). Blood pressure, blood lipids, safety measures, side effects, and diet were evaluated throughout the trial. After completion of treatment, a 4-week follow-up was conducted. There was a mean reduction of 8.0+/-3.2 mm Hg in systolic blood pressure (P<.05) and of 5.5+/-2.1 mm Hg in diastolic blood pressure (P<.05) in the treatment group compared with the control group. Low-density lipoprotein cholesterol and high-sensitivity C-reactive protein were significantly improved by treatment. Whey-derived peptides might be a viable treatment option for prehypertensive and/or stage 1 hypertensive populations.
Joel J Pins; Joseph M Keenan
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Retracted Publication    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  8     ISSN:  1524-6175     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2007-01-30     Revised Date:  2008-09-30    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  775-82     Citation Subset:  IM    
Department of Family Medicine and Community Health, University of Minnesota Medical School, Hypertension and Cholesterol Research Center, Minneapolis, MN 5545, USA.
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MeSH Terms
Blood Pressure / physiology
Cardiovascular Diseases / blood,  diet therapy*,  physiopathology
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Double-Blind Method
Follow-Up Studies
Middle Aged
Milk Proteins / therapeutic use*
Pilot Projects
Treatment Outcome
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Milk Proteins; 0/Triglycerides; 0/whey protein
Retraction In:
J Clin Hypertens (Greenwich). 2008 Aug;10(8):631   [PMID:  18780483 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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