Document Detail


Effects of weight loss and seafood consumption on inflammation parameters in young, overweight and obese European men and women during 8 weeks of energy restriction.
MedLine Citation:
PMID:  20551965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/OBJECTIVES: In vitro studies have shown that long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) can affect inflammation; however, results from intervention studies in overweight or obese individuals are contradicting. The aim of this study was to investigate the effects of weight loss and seafood consumption on inflammation parameters during energy restriction.
SUBJECTS/METHODS: In this 8-week intervention trial, 324 subjects (aged 20-40 years, body mass index 27.5-32.5 kg/m(2) from Iceland, Spain and Ireland) were randomized to one of four energy-restricted diets (-30% relative to estimated requirements): salmon (3 x 150 g/week, 2.1 g LC n-3 PUFA per day); cod (3 x 150 g/week, 0.3 g LC n-3 PUFA per day); fish oil capsules (1.3 g LC n-3 PUFA per day); and control (sunflower oil capsules, no seafood). Body weight, high-sensitivity C-reactive protein (CRP), interleukin-6 (IL-6), glutathione reductase and prostaglandin F2 alpha (PGEF2alpha) were measured at baseline and end point.
RESULTS: Subjects experienced weight loss (-5.2+/-3.2 kg, P<0.001). Taken together for all subjects, there were significant decreases in all inflammation parameters. On a group level, salmon consumption was most effective, three of the four inflammation parameters decreased in the salmon group (high-sensitivity CRP=-32.0%; IL-6=-18.4%; PGEF2alpha=-18.5%; all P<0.05). Cod consumption decreased high-sensitivity CRP and IL-6 (-21.5 and -10.8%, respectively, both P<0.05). Changes in the other two groups were not significant, which can be partly explained by the large s.d.
CONCLUSIONS: The mean concentrations of inflammation parameters decreased during a period of weight loss and dietary intervention. In our study, salmon consumption was most effective, three of the four measured inflammation parameters decreased significantly in the salmon group.
Authors:
A Ramel; J A Martinez; M Kiely; N M Bandarra; I Thorsdottir
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-06-16
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  64     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  987-93     Citation Subset:  IM    
Affiliation:
Unit for Nutrition Research, Landspitali University Hospital, University of Iceland, Reykjavik, Iceland. alfons@landspitali.is
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00315770
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
C-Reactive Protein / metabolism
Caloric Restriction
Diet, Reducing*
Dietary Supplements
Dinoprost / blood
Fatty Acids, Omega-3 / administration & dosage*
Female
Fish Oils / administration & dosage
Gadus morhua
Glutathione Reductase / blood
Humans
Iceland
Inflammation / blood*,  epidemiology
Interleukin-6 / blood
Ireland
Male
Obesity / blood*,  diet therapy
Overweight / blood*,  diet therapy
Salmon
Seafood* / analysis
Spain
Weight Loss / physiology*
Young Adult
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Interleukin-6; 551-11-1/Dinoprost; 9007-41-4/C-Reactive Protein; EC 1.8.1.7/Glutathione Reductase

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