| Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women. | |
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MedLine Citation:
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PMID: 20631298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma lipoproteins and glucose homeostasis were evaluated after marked weight loss before and over 12 months following Roux-en-Y gastric-bypass (RYGBP) surgery in 19 morbidly obese women. Standard lipids, remnant-lipoprotein cholesterol (RLP-C); HDL-triglyceride (TG); apolipoproteins (apo) A-I, A-II, E, and A-I-containing HDL subpopulations; lecithin-cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) mass and activity; plasma glucose and insulin levels were measured before and at 1, 3, 6, and 12 months after GBP surgery. Baseline concentrations of TG, RLP-C, glucose, and insulin were significantly higher in obese than in normal-weight, age-matched women, whereas HDL cholesterol (HDL-C), apoA-I, apoA-II, alpha-1 and alpha-2 levels were significantly lower. Over 1 year, significant decreases of body mass index, glucose, insulin, TG, RLP-C, HDL-TG, and prebeta-1 levels were observed with significant increases of HDL-C and alpha-1 levels (all P < 0.05). Changes of fat mass were correlated with those of LDL cholesterol (P = 0.018) and LCAT mass (P = 0.011), but not with CETP mass (P = 0.265). Changes of fasting plasma glucose concentrations were inversely correlated with those of CETP mass (P = 0.005) and alpha-1 level (P = 0.004). Changes of fasting plasma insulin concentrations were positively correlated with those of LCAT mass (P = 0.043) and inversely with changes of alpha-1 (P = 0.03) and alpha-2 (P = 0.05) concentrations. These results demonstrate beneficial changes in HDL remodeling following substantial weight loss induced by RYGBP surgery and that these changes are associated with improvement of glucose homeostasis in these patients. |
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Authors:
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Bela F Asztalos; Michael M Swarbrick; Ernst J Schaefer; Gerard E Dallal; Katalin V Horvath; Masumi Ai; Kimber L Stanhope; Iselin Austrheim-Smith; Bruce M Wolfe; Mohamed Ali; Peter J Havel |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of lipid research Volume: 51 ISSN: 0022-2275 ISO Abbreviation: J. Lipid Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-10-20 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: United States |
Other Details:
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Languages: eng Pagination: 2405-12 Citation Subset: IM |
Affiliation:
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Lipid Metabolism Laboratory, Human Nutrition Research Center at Tufts University, Boston, MA, USA. bela.asztalos@tufts.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Adult Biological Markers / metabolism Cardiovascular Diseases / metabolism Case-Control Studies Cholesterol Ester Transfer Proteins / metabolism Female Gastric Bypass* Humans Lipoproteins, HDL / metabolism* Obesity, Morbid / metabolism*, pathology, physiopathology, surgery* Phosphatidylcholine-Sterol O-Acyltransferase / metabolism Risk Weight Loss* |
| Grant Support | |
ID/Acronym/Agency:
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AT-002599/AT/NCCAM NIH HHS; AT-002933/AT/NCCAM NIH HHS; AT-003645/AT/NCCAM NIH HHS; HL-075675/HL/NHLBI NIH HHS; HL-091333/HL/NHLBI NIH HHS; HL-64738/HL/NHLBI NIH HHS; RR-024146/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/CETP protein, human; 0/Cholesterol Ester Transfer Proteins; 0/Lipoproteins, HDL; EC 2.3.1.43/Phosphatidylcholine-Sterol O-Acyltransferase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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