| Effects of weaning cereals with different phytate contents on hemoglobin, iron stores, and serum zinc: a randomized intervention in infants from 6 to 12 mo of age. | |
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MedLine Citation:
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PMID: 12816787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Weaning foods frequently contain phytate, an inhibitor of iron and zinc absorption, which may contribute to the high prevalence of iron and zinc deficiency seen in infancy. OBJECTIVE: The objective was to investigate whether either an extensive reduction in the phytate content of infant cereals or the use of milk-based, iron-fortified infant formula would improve iron and zinc status in infants. DESIGN: In a double-blind design, infants (n = 300) were randomly assigned to 3 cereal groups from 6 to 12 mo of age: commercial milk-based cereal drink (MCD) and porridge (CC group), phytate-reduced MCD and phytate-reduced porridge (PR group), or milk-based infant formula and porridge with the usual phytate content (IF group). Venous blood samples were collected at 6 and 12 mo. Dietary intake was recorded monthly. After the intervention, 267 infants remained in the analysis. RESULTS: Hemoglobin concentrations of < 110 g/L, serum ferritin concentrations of < 12 microg/L, and serum zinc concentrations of < 10.7 micromol/L had overall prevalences at baseline and 12 mo of 28% and 15%, 9% and 18%, and 22% and 27%, respectively. After the intervention, there were no significant differences in any measure of iron or zinc status between the CC and the PR groups. However, hemoglobin was significantly higher (120 g/L compared with 117 g/L; P = 0.012) and the prevalence of anemia was lower (13% compared with 23%; P = 0.06) in the PR group than in the IF group, which could be explained by differences in daily iron intake between the 2 groups. CONCLUSION: Extensive reduction in the phytate content of weaning cereals had little long-term effect on the iron and zinc status of Swedish infants. |
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Authors:
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Torbjörn Lind; Bo Lönnerdal; Lars-Ake Persson; Hans Stenlund; Catharina Tennefors; Olle Hernell |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 78 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-06-20 Completed Date: 2003-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 168-75 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden. torbjorn.lind@epiph.umu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
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epidemiology Cereals / chemistry* Diet Double-Blind Method Ferritins / blood Food, Fortified Hemoglobins / analysis* Humans Infant Infant Food / analysis Iron / administration & dosage, blood* Phytic Acid / analysis* Prevalence Weaning* Zinc / blood* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 7439-89-6/Iron; 7440-66-6/Zinc; 83-86-3/Phytic Acid; 9007-73-2/Ferritins |
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