Document Detail


Effects of warm-up on exercise capacity, platelet activation and platelet-leucocyte aggregation in patients with claudication.
MedLine Citation:
PMID:  15505876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The effects of exercise and warm-up were investigated in patients with claudication. METHODS: This case-control crossover study involved two treadmill exercise tests, one preceded by a warm-up. Exercise continued until maximal leg pain (patients with claudication) or exhaustion (controls). Blood was taken before, and 5 and 60 min after exercise for flow cytometric analysis of platelet activation and platelet-leucocyte aggregation. RESULTS: Both cohorts (eight patients with claudication of median age 63 years and eight healthy controls of median age 63.5 years) demonstrated improvement in exercise capacity after warm-up (13.1 per cent, P = 0.012 and 15.6 per cent, P = 0.008 respectively). Platelet activation increased after exercise in patients with claudication (fibrinogen binding: 1.11 per cent before exercise versus 2.63 per cent after exercise, P = 0.008; P-selectin: 0.68 versus 1.11 per cent, P = 0.028). Neither agonist stimulation nor warm-up altered this trend. Platelet-leucocyte (PLA) and platelet-neutrophil (PNA) aggregation were similarly increased immediately after exercise in patients with claudication (PLA: 7.6 versus 13.0 per cent, P = 0.004; PNA: 6.8 versus 10.2 per cent, P = 0.012). These remained high 60 min after exercise only in patients with claudication, but recovered to baseline levels when preceded by warm-up. Warm-up significantly desensitized PNA after stimulation with 10 micromol/l adenosine 5'-diphosphate at all time points. CONCLUSION: Warm-up increased the exercise capacity of patients with claudication. Exercise induced a thromboinflammatory response, with PLA and PNA persistently increased after 60 min in patients with claudication, an effect diminished after warm-up.
Authors:
S Pasupathy; K M Naseem; S Homer-Vanniasinkam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of surgery     Volume:  92     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-11     Completed Date:  2005-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  AIM; IM    
Affiliation:
Vascular Surgical Unit, Leeds General Infirmary, Leeds, Bradford, UK.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / pharmacology
Aged
Case-Control Studies
Cohort Studies
Cross-Over Studies
Exercise / physiology*
Exercise Test / methods
Female
Fibrinogen / metabolism
Flow Cytometry / methods
Humans
Intermittent Claudication / blood,  metabolism*,  physiopathology
Leukocytes / metabolism*
Male
Middle Aged
Neutrophil Activation / physiology
Neutrophils / metabolism
P-Selectin / metabolism
Platelet Activation / physiology*
Platelet Aggregation / physiology
Chemical
Reg. No./Substance:
0/P-Selectin; 58-64-0/Adenosine Diphosphate; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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