Document Detail

Effects of warfarin on blood pressure in men with diabetes and hypertension--a longitudinal study.
MedLine Citation:
PMID:  17396067     Owner:  NLM     Status:  MEDLINE    
Warfarin causes extensive vascular calcification leading to increased systolic blood pressure and pulse pressure in rats, may be associated with increased valvular and coronary calcifications in man, and possibly worsens hypertension in high-risk patients, particularly in those with diabetes mellitus or uncontrolled hypertension. The authors evaluated blood pressure and intensity of antihypertensive therapy over 36 months in a cohort of 58 patients with diabetes and hypertension on warfarin and 58 control subjects with diabetes and hypertension not on warfarin. The results demonstrate that warfarin therapy at conventional doses does not increase systolic blood pressure or pulse pressure in patients with diabetes and hypertension.
Mary Ann Lim; Shahzad Shafique; Sein Yin See; Faisal N Khan; Chirag R Parikh; Aldo J Peixoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  9     ISSN:  1524-6175     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-30     Completed Date:  2007-08-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-8     Citation Subset:  IM    
Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA.
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MeSH Terms
Aged, 80 and over
Anticoagulants / adverse effects*
Antihypertensive Agents / administration & dosage*
Blood Pressure / drug effects*
Controlled Clinical Trials as Topic
Diabetes Mellitus / physiopathology*
Dose-Response Relationship, Drug
Follow-Up Studies
Hypertension / drug therapy,  physiopathology*
Longitudinal Studies
Regression Analysis
Research Design
Treatment Outcome
Warfarin / adverse effects*
Reg. No./Substance:
0/Anticoagulants; 0/Antihypertensive Agents; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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