Document Detail

Effects of voluntary physical exercise on cardiac function and energetics in spontaneously hypertensive rats.
MedLine Citation:
PMID:  3227935     Owner:  NLM     Status:  MEDLINE    
The influence of voluntary physical exercise in running wheels on myocardial function, cardiac oxygen utilization and cardiovascular response to emotional stress was analysed in the spontaneously hypertensive rat. After 6 weeks of exercise, a significant increase in resting cardiac output was found, which was due to an elevation of stroke volume. However, voluntary training for 12 weeks had no effect on resting blood pressure or on the blood-pressure response to mental stress. Cardiac function was also examined in vitro. At a low aortic diastolic pressure, it was markedly augmented in trained spontaneously hypertensive rats. At high aortic diastolic pressure, maximal cardiac function was similar in the two groups. Myocardial oxygen consumption (mumol min-1 g-1) for a given level of external work was reduced in trained, compared with non-exercised control spontaneously hypertensive rats. Chronic physical exercise thus greatly improved myocardial function at a subnormal perfusion pressure, suggesting better nutritional supply to the myocardium, probably created by an increased capillary surface area.
P Friberg; P Hoffmann; M Nordlander; P Thoren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  133     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1989-03-27     Completed Date:  1989-03-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  495-500     Citation Subset:  IM    
Department of Physiology, University of Göteborg, Sweden.
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MeSH Terms
Blood Pressure
Heart Rate
Myocardium / metabolism*
Oxygen Consumption
Physical Exertion*
Rats, Inbred SHR
Stress, Psychological / physiopathology

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