Document Detail

Effects of volume expansion on cardiac output in the preterm infant.
MedLine Citation:
PMID:  9401521     Owner:  NLM     Status:  MEDLINE    
Clinical and echocardiographic haemodynamic evaluations of response to volume expansion are described in 12 preterm neonates aged < 7 days presenting without cardiac dysfunction and with a low cardiac output. They received 10% albumin solution (20 ml kg-1) for 3 h. Measurements were made before infusion, at volumes 5, 12.5 and 20 ml kg-1 and 1 h later. All infants increased significantly their cardiac output (CO) (from a median of 177 to 283 ml kg-1 min-1). The rise of CO decreased with the volume infused. The index of systemic vascular resistance (SVR = ratio of mean arterial pressure to the CO) decreased for the six patients without PDA (from 272 to 193 mmHg l-1 kg-1 min-1, p < 0.05) showing that the hypovolaemic preterm infant is able to shut down peripherally in response to hypovolaemia. The four hypotensive infants responded by increasing mean arterial blood pressure (from 29 to 44 mmHg). Cutaneous refilling time decreased during infusion (from 6.7 to 3.8 s. p < 0.01). One infant had an haemodynamically significant ductus arteriosus revealed by volume expansion, another one developed myocardial dysfunction.
P Pladys; E Wodey; P Bétrémieux; A Beuchée; C Ecoffey
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  86     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-13     Completed Date:  1998-01-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1241-5     Citation Subset:  IM    
Neonatal Intensive Care Unit, University Hospital, Rennes, France.
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MeSH Terms
Albumins / administration & dosage*
Birth Weight
Cardiac Output, Low / physiopathology,  therapy*
Echocardiography, Doppler
Gestational Age
Infant, Newborn
Infant, Premature / physiology*
Infant, Premature, Diseases / physiopathology,  therapy*
Infusions, Intravenous
Intensive Care Units, Neonatal
Reproducibility of Results
Reg. No./Substance:

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