Document Detail

Effects of vitamin E on reactive oxygen species-mediated 2,3,7,8-tetrachlorodi-benzo-p-dioxin toxicity in rat testis.
MedLine Citation:
PMID:  12355564     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to investigate whether treatment with vitamin E protects rat testis from oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Male rats of Wistar strain were administered TCDD at doses of 1, 10 and 100 ng kg(-1) body wt. day(-1) for 45 days. Other groups of animals were co-administered TCDD (1, 10 and 100 ng kg(-1) body wt. day(-1)) and vitamin E (20 mg kg(-1) body wt. day(-1)) for 45 days. Animals administered TCDD and those co-administered TCDD and vitamin E did not show any significant change in body weight. Administration of TCDD decreased the weights of the testis, epididymis, seminal vesicles and ventral prostate. The daily sperm production decreased in the animals administered TCDD from the control values of 22.19 +/- 2.67 to 13.10 +/- 3.16 x 10(6). There was a significant decline in the activities of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase with concomitant increased levels of hydrogen peroxide and lipid peroxidation. Co-administration of TCDD and vitamin E did not show any significant changes in the weights of the testis, epididymis, seminal vesicles and ventral prostate. The daily sperm production remained unchanged in the animals co-administered TCDD and vitamin E. The activities of antioxidant enzymes and the levels of hydrogen peroxide and lipid peroxidation did not change in the animals co-administered TCDD and vitamin E. The results suggested that administration of TCDD induces oxidative stress in testis, and vitamin E could impart a protective effect against TCDD-induced oxidative stress.
C Latchoumycandane; P P Mathur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  22     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:    2002 Sep-Oct
Date Detail:
Created Date:  2002-09-30     Completed Date:  2003-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  IM    
Copyright Information:
Copyright 2002 John Wiley & Sons, Ltd.
School of Life Sciences, Pondicherry University, Pondicherry 605 014, India.
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MeSH Terms
Antioxidants / pharmacology*
Body Weight / drug effects
Dose-Response Relationship, Drug
Drug Interactions
Environmental Pollutants / toxicity*
Organ Size / drug effects
Oxidative Stress*
Rats, Wistar
Reactive Oxygen Species / metabolism*
Sperm Count
Spermatozoa / drug effects
Testis / drug effects*,  enzymology,  pathology
Tetrachlorodibenzodioxin / toxicity*
Vitamin E / pharmacology*
Reg. No./Substance:
0/Antioxidants; 0/Environmental Pollutants; 0/Reactive Oxygen Species; 1406-18-4/Vitamin E; 1746-01-6/Tetrachlorodibenzodioxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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