Document Detail


Effects of vitamin E on clinic and ambulatory blood pressure in treated hypertensive patients. Collaborative Group of the Primary Prevention Project (PPP)--Hypertension study.
MedLine Citation:
PMID:  10826412     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A randomized controlled open trial studied the effect of vitamin E supplementation (300 mg/day) on clinic and 24-h ambulatory blood pressure (BP) in 142 treated hypertensive patients. After 12 weeks, clinic BP decreased whether or not patients were randomized to vitamin E. Ambulatory BP showed no change in systolic BP and a small decrease in diastolic BP (-1.6 mm Hg, 95% confidence intervals from -2.8 to -0.4 mm Hg), approaching statistical significance in comparison to the control group (P = .06). Vitamin E supplementation thus seems to have no clinically relevant effect on BP in hypertensive patients already under controlled treatment.
Authors:
G Palumbo; F Avanzini; C Alli; M C Roncaglioni; E Ronchi; M Cristofari; A Capra; S Rossi; L Nosotti; C Costantini; C Cavalera
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  13     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-09-12     Completed Date:  2000-09-12     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  564-7     Citation Subset:  IM    
Affiliation:
San Carlo Borromeo Hospital, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects*,  physiology
Blood Pressure Monitoring, Ambulatory*
Circadian Rhythm / physiology*
Confidence Intervals
Dietary Supplements*
Drug Therapy, Combination
Female
Humans
Hypertension / drug therapy,  physiopathology*
Male
Middle Aged
Vitamin E / therapeutic use*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 1406-18-4/Vitamin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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