Document Detail


Effects of vitamin E, vitamin C and polyphenols on the rate of blood pressure variation: results of two randomised controlled trials.
MedLine Citation:
PMID:  25234339     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
High blood pressure (BP) variability, which may be an important determinant of hypertensive end-organ damage, is emerging as an important predictor of cardiovascular health. Dietary antioxidants can influence BP, but their effects on variability are yet to be investigated. The aim of the present study was to assess the effects of vitamin E, vitamin C and polyphenols on the rate of daytime and night-time ambulatory BP variation. To assess these effects, two randomised, double-blind, placebo-controlled trials were performed. In the first trial (vitamin E), fifty-eight individuals with type 2 diabetes were given 500 mg/d of RRR-α-tocopherol, 500 mg/d of mixed tocopherols or placebo for 6 weeks. In the second trial (vitamin C-polyphenols), sixty-nine treated hypertensive individuals were given 500 mg/d of vitamin C, 1000 mg/d of grape-seed polyphenols, both vitamin C and polyphenols, or neither (placebo) for 6 weeks. At baseline and at the end of the 6-week intervention, 24 h ambulatory BP and rate of measurement-to-measurement BP variation were assessed. Compared with placebo, treatment with α-tocopherol, mixed tocopherols, vitamin C and polyphenols did not significantly alter the rate of daytime or night-time systolic BP, diastolic BP or pulse pressure variation (P>0·05). Treatment with the vitamin C and polyphenol combination resulted in higher BP variation: the rate of night-time systolic BP variation (P= 0·022) and pulse pressure variation (P= 0·0036) were higher and the rate of daytime systolic BP variation was higher (P= 0·056). Vitamin E, vitamin C or grape-seed polyphenols did not significantly alter the rate of BP variation. However, the increase in the rate of BP variation suggests that the combination of high doses of vitamin C and polyphenols could be detrimental to treated hypertensive individuals.
Authors:
Jonathan M Hodgson; Kevin D Croft; Richard J Woodman; Ian B Puddey; Catherine P Bondonno; Jason H Y Wu; Lawrence J Beilin; Elena V Lukoshkova; Geoffrey A Head; Natalie C Ward
Related Documents :
10527249 - Adapting prognostic respiratory variables of ards in children to small-scale community ...
6481579 - The "critical" neonate with diaphragmatic hernia: a 21-year perspective.
25234339 - Effects of vitamin e, vitamin c and polyphenols on the rate of blood pressure variation...
18751599 - Battery life of the "four-hour" lithium ion battery of the ltv-1000 under varying workl...
6391819 - Bronchiolectasis caused by positive end-expiratory pressure.
10548209 - The ventilatory effects of auto-positive end-expiratory pressure development during car...
6305729 - New evidence for brain angiotensin and for its role in hypertension.
10929779 - Standardized ejection fraction as a parameter of overall ventricular pump function.
2677089 - Left subclavian flap aortoplasty for coarctation of the aorta: effects on forearm vascu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-19
Journal Detail:
Title:  The British journal of nutrition     Volume:  -     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-11     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of Ionic Charge on the CH···? Hydrogen Bond.
Next Document:  Emerging drugs for schizophrenia: an update.