Document Detail


Effects of vitamin D. A comparison of 1 alpha OHD2 and 1 alpha OHD3 in rats.
MedLine Citation:
PMID:  3911723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of 1 alpha OHD2 and 1 alpha OHD3 have been studied in rachitic, normal, and prednisolone-treated male rats. The healing of rickets, the stimulation of intestinal Ca and P transport, the effect on bone mineral, and the induction of renal calcifications have been examined. The two 1-hydroxylated compounds are equally potent in healing rickets, and by comparison with previous data are equivalent to 100-200 IU/micrograms. 1 alpha OHD2 and 1 alpha OHD3 stimulated intestinal Ca and P transport to the same extent and were antagonistic to prednisolone in this respect. 1 alpha OHD2 reduced the number of osteoclasts and increased bone mineral in normal rats in contrast to 1 alpha OHD3, which increased osteoclasts and slightly reduced bone mineral. Prednisolone-induced osteopenia was more effectively counteracted by 1 alpha OHD2 than by 1 alpha OHD3. Mortality rate was higher in rats intoxicated with 1 alpha OHD3 than for rats given 1 alpha OHD2. LD50 was estimated to be five to fifteen times higher for 1 alpha OHD2. Renal calcification were more pronounced after dosing with 1 alpha OHD3 than after treatment with 1 alpha OHD2. When prednisolone was given together with 1 alpha OHD2 or 1 alpha OHD3, renal calcifications were further increased. These observations demonstrate physiological dissimilarities between vitamin D2 and vitamin D3 in rats which are in accordance with a different metabolism of the two vitamins. The findings, in particular that 1 alpha OHD2 is less toxic than 1 alpha OHD3, are of potential clinical importance.
Authors:
G Sjödén
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta orthopaedica Scandinavica. Supplementum     Volume:  217     ISSN:  0300-8827     ISO Abbreviation:  Acta Orthop Scand Suppl     Publication Date:  1985  
Date Detail:
Created Date:  1986-03-17     Completed Date:  1986-03-17     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  0370353     Medline TA:  Acta Orthop Scand Suppl     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport / drug effects
Bone and Bones / drug effects
Calcium / metabolism
Ergocalciferols / analogs & derivatives*,  pharmacology
Humans
Hydroxycholecalciferols / pharmacology*
Hypoparathyroidism / etiology
Intestinal Absorption / drug effects
Intestines / drug effects
Kidney / drug effects,  metabolism
Liver / metabolism
Osteomalacia / etiology
Osteoporosis / etiology
Phosphorus / metabolism
Prednisolone / pharmacology
Rats
Renal Osteodystrophy / etiology
Rickets / drug therapy,  etiology
Skin / metabolism
Vitamin D / physiology,  toxicity
Chemical
Reg. No./Substance:
0/Ergocalciferols; 0/Hydroxycholecalciferols; 1406-16-2/Vitamin D; 50-24-8/Prednisolone; 54573-75-0/1 alpha-hydroxyergocalciferol; 7440-70-2/Calcium; 7723-14-0/Phosphorus; URQ2517572/alfacalcidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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