| Effects of vitamin C supplementation on antioxidants and lipid peroxidation markers in elderly subjects with type 2 diabetes. | |
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MedLine Citation:
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PMID: 18077012 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of our study was to evaluate the effects of the administration of two dosages of vitamin C (Vit-C) (0.5 and 1g/day, vs. placebo) in elderly patients with type 2 diabetes mellitus on the intracellular levels of Vit-C and glutathione, and on the lipid peroxidation markers and vitamin E (Vit-E) content of low-density lipoprotein (LDL) and on LDL susceptibility to gamma radiolysis-induced peroxidation. Thirty-six patients were randomized into three groups. In patients on 0.5 g Vit-C/day versus the placebo group, a significant increase in cellular reduced glutathione level was observed (0.60+/-0.26 vs. 0.33+/-0.27). In patients on 1 g Vit-C/day versus placebo, a significant increase was also observed in cellular reduced glutathione (0.93+/-0.70 vs. 0.33+/-0.27), in Vit-C (5.66+/-2.00 vs. 2.72+/-1.88) and in vitamin E content of LDL (1.98+/-0.38 vs. 1.48+/-0.40). No change was observed in either group in basal levels of lipid peroxidation markers and in the susceptibility of LDL to peroxidation provoked by gamma-radiolysis. In conclusion, Vit-C has a dose-dependent effect on the cellular contents of antioxidants and on vitamin E content of LDL in elderly patients with type 2 DM. These changes are not sufficient to decrease the LDL susceptibility to peroxidation. |
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Authors:
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Daniel M Tessier; Abdelouahed Khalil; Lise Trottier; Tamas Fülöp |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2008-02-20 |
Journal Detail:
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Title: Archives of gerontology and geriatrics Volume: 48 ISSN: 1872-6976 ISO Abbreviation: Arch Gerontol Geriatr Publication Date: 2009 Jan-Feb |
Date Detail:
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Created Date: 2008-12-02 Completed Date: 2009-04-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214379 Medline TA: Arch Gerontol Geriatr Country: Netherlands |
Other Details:
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Languages: eng Pagination: 67-72 Citation Subset: IM |
Affiliation:
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Biogerontology Laboratory, Research Center on Aging, Sherbrooke Geriatric University Institute, 375 Rue Argyll, Sherbrooke, QC J1J 3H5, Canada. dtessier.csss-iugs@ssss.gouv.qc.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antioxidants / metabolism* Ascorbic Acid / administration & dosage* Biological Markers / blood* Chromatography, High Pressure Liquid Diabetes Mellitus, Type 2 / blood*, drug therapy Dietary Supplements* Dose-Response Relationship, Drug Female Follow-Up Studies Humans Lipid Peroxidation / drug effects, physiology* Lipoproteins / blood Male Oxidative Stress / physiology Treatment Outcome Vitamins / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 0/Lipoproteins; 0/Vitamins; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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