Document Detail

Effects of vitamin C supplementation on acute phase Chagas disease in experimentally infected mice with Trypanosoma cruzi QM1 strain.
MedLine Citation:
PMID:  23152316     Owner:  NLM     Status:  In-Data-Review    
The tissue changes that occur in Chagas disease are related to the degree of oxidative stress and antioxidant capacity of affected tissue. Studies with vitamin C supplementation did not develop oxidative damage caused by Chagas disease in the host, but other studies cite the use of peroxiredoxins ascorbate - dependent on T. cruzi to offer protection against immune reaction. Based on these propositions, thirty "Swiss" mice were infected with T. cruzi QM1 strain and treated with two different vitamin C doses in order to study the parasitemia evolution, histopathological changes and lipid peroxidation biomarkers during the acute phase of Chagas disease. The results showed that the parasite clearance was greater in animals fed with vitamin C overdose. There were no significant differences regarding the biomarkers of lipid peroxidation and inflammatory process or the increase of myocardium in animals treated with the recommended dosage. The largest amount of parasite growth towards the end of the acute phase suggests the benefit of high doses of vitamin C for trypomastigotes. The supplementation doesn't influence the production of free radicals or the number of amastigote nests in the acute phase of Chagas disease.
Ricardo Guimarães Marim; Alex Silva de Gusmão; Roberto Esteves Pires Castanho; Rafael Deminice; Altino Luiz Silva Therezo; Alceu Afonso Jordão Júnior; Luciamare Perinetti Alves Martins
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista do Instituto de Medicina Tropical de São Paulo     Volume:  54     ISSN:  1678-9946     ISO Abbreviation:  Rev. Inst. Med. Trop. Sao Paulo     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7507484     Medline TA:  Rev Inst Med Trop Sao Paulo     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  319-23     Citation Subset:  IM    
Department of Parasitology of Marília Medical School, FAMEMA, Marília, São Paulo, Brazil, 17519-070.
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