| Effects of vitamin B12 and folate deficiency on brain development in children. | |
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MedLine Citation:
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PMID: 18709887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Folate deficiency in the periconceptional period contributes to neural tube defects; deficits in vitamin B12 (cobalamin) have negative consequences on the developing brain during infancy; and deficits of both vitamins are associated with a greater risk of depression during adulthood. This review examines two mechanisms linking folate and vitamin B12 deficiency to abnormal behavior and development in infants: disruptions to myelination and inflammatory processes. Future investigations should focus on the relationship between the timing of deficient and marginal vitamin B12 status and outcomes such as infant growth, cognition, social development, and depressive symptoms, along with prevention of folate and vitamin B12 deficiency. |
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Authors:
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Maureen M Black |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Food and nutrition bulletin Volume: 29 ISSN: 0379-5721 ISO Abbreviation: Food Nutr Bull Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-08-19 Completed Date: 2008-11-10 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 7906418 Medline TA: Food Nutr Bull Country: Japan |
Other Details:
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Languages: eng Pagination: S126-31 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. mblack@peds.umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Brain / drug effects, growth & development* Child Child, Preschool Depression / epidemiology*, prevention & control, psychology Female Folic Acid / blood, therapeutic use Folic Acid Deficiency / complications, psychology* Humans Infant Infant, Newborn Male Middle Aged Neural Tube Defects / epidemiology*, prevention & control, psychology Nutritional Status Pregnancy Prenatal Exposure Delayed Effects Vitamin B 12 / blood, therapeutic use Vitamin B 12 Deficiency / complications, psychology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD037430-01/HD/NICHD NIH HHS; R01 HD037430-02/HD/NICHD NIH HHS; R01 HD037430-03/HD/NICHD NIH HHS; R01 HD037430-04/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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59-30-3/Folic Acid; 68-19-9/Vitamin B 12 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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