Document Detail


Effects of vitamin B12 and folate deficiency on brain development in children.
MedLine Citation:
PMID:  18709887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Folate deficiency in the periconceptional period contributes to neural tube defects; deficits in vitamin B12 (cobalamin) have negative consequences on the developing brain during infancy; and deficits of both vitamins are associated with a greater risk of depression during adulthood. This review examines two mechanisms linking folate and vitamin B12 deficiency to abnormal behavior and development in infants: disruptions to myelination and inflammatory processes. Future investigations should focus on the relationship between the timing of deficient and marginal vitamin B12 status and outcomes such as infant growth, cognition, social development, and depressive symptoms, along with prevention of folate and vitamin B12 deficiency.
Authors:
Maureen M Black
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Food and nutrition bulletin     Volume:  29     ISSN:  0379-5721     ISO Abbreviation:  Food Nutr Bull     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-08-19     Completed Date:  2008-11-10     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  7906418     Medline TA:  Food Nutr Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  S126-31     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. mblack@peds.umaryland.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Brain / drug effects,  growth & development*
Child
Child, Preschool
Depression / epidemiology*,  prevention & control,  psychology
Female
Folic Acid / blood,  therapeutic use
Folic Acid Deficiency / complications,  psychology*
Humans
Infant
Infant, Newborn
Male
Middle Aged
Neural Tube Defects / epidemiology*,  prevention & control,  psychology
Nutritional Status
Pregnancy
Prenatal Exposure Delayed Effects
Vitamin B 12 / blood,  therapeutic use
Vitamin B 12 Deficiency / complications,  psychology*
Grant Support
ID/Acronym/Agency:
R01 HD037430-01/HD/NICHD NIH HHS; R01 HD037430-02/HD/NICHD NIH HHS; R01 HD037430-03/HD/NICHD NIH HHS; R01 HD037430-04/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
59-30-3/Folic Acid; 68-19-9/Vitamin B 12
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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