Document Detail

Effects of vitamin B12 and folate deficiency on brain development in children.
MedLine Citation:
PMID:  18709887     Owner:  NLM     Status:  MEDLINE    
Folate deficiency in the periconceptional period contributes to neural tube defects; deficits in vitamin B12 (cobalamin) have negative consequences on the developing brain during infancy; and deficits of both vitamins are associated with a greater risk of depression during adulthood. This review examines two mechanisms linking folate and vitamin B12 deficiency to abnormal behavior and development in infants: disruptions to myelination and inflammatory processes. Future investigations should focus on the relationship between the timing of deficient and marginal vitamin B12 status and outcomes such as infant growth, cognition, social development, and depressive symptoms, along with prevention of folate and vitamin B12 deficiency.
Maureen M Black
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Food and nutrition bulletin     Volume:  29     ISSN:  0379-5721     ISO Abbreviation:  Food Nutr Bull     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-08-19     Completed Date:  2008-11-10     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7906418     Medline TA:  Food Nutr Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  S126-31     Citation Subset:  IM    
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MeSH Terms
Brain / drug effects,  growth & development*
Child, Preschool
Depression / epidemiology*,  prevention & control,  psychology
Folic Acid / blood,  therapeutic use
Folic Acid Deficiency / complications,  psychology*
Infant, Newborn
Middle Aged
Neural Tube Defects / epidemiology*,  prevention & control,  psychology
Nutritional Status
Prenatal Exposure Delayed Effects
Vitamin B 12 / blood,  therapeutic use
Vitamin B 12 Deficiency / complications,  psychology*
Grant Support
R01 HD037430/HD/NICHD NIH HHS; R01 HD037430-01/HD/NICHD NIH HHS; R01 HD037430-02/HD/NICHD NIH HHS; R01 HD037430-03/HD/NICHD NIH HHS; R01 HD037430-04/HD/NICHD NIH HHS
Reg. No./Substance:
935E97BOY8/Folic Acid; P6YC3EG204/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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