| Effects of vinyl chloride on liver function of exposed workers, evaluated by measurements of plasma clearance of the 99mTc-N-2,4-dimethylacetanilido-iminodiacetate complex. | |
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MedLine Citation:
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PMID: 2778253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 77 males exposed occupationally to vinyl chloride (VC), the plasma clearance (Cl) of 99mTc-N(2,4-dimethylacetanilido)iminodiacetate ('HEPIDA' complex) was determined. The results were juxtaposed with a scaled assessment of liver parenchyma performance based upon clinical examination and a series of biochemical tests. Detection of the diagnosable damage of liver parenchyma by means of the reduced clearance was sensitive (90%) at the reasonable specificity of 74%. Probability of exclusion of liver damage in patients with the clearance above 240 ml min-1 1.73 m-2 amounted to 92%. There was a significant correlation between degree of exposure to VC and the frequency of low clearance values. It appears that the periodic determination of the 99mTc-HEPIDA clearance in workers exposed to VC allows the assessment of incipient liver damage and signals the need for prophylactic measures. |
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Authors:
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M Studniarek; K Durski; J Liniecki; D Brykalski; A Poznańska; M Głuszcz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied toxicology : JAT Volume: 9 ISSN: 0260-437X ISO Abbreviation: J Appl Toxicol Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-10-26 Completed Date: 1989-10-26 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8109495 Medline TA: J Appl Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 213-8 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Medical Academy, Lodz, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Drug-Induced Liver Injury / physiopathology* Humans Imino Acids / diagnostic use* Liver Function Tests Male Middle Aged Occupational Diseases / chemically induced*, physiopathology Organometallic Compounds / diagnostic use* Technetium / diagnostic use* Technetium Tc 99m Diethyl-iminodiacetic Acid Vinyl Chloride / toxicity* Vinyl Compounds / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Imino Acids; 0/Organometallic Compounds; 0/Technetium Tc 99m Diethyl-iminodiacetic Acid; 0/Vinyl Compounds; 7440-26-8/Technetium; 75-01-4/Vinyl Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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