| Effects of vinblastine on microvascular anastomosis healing in diabetic rats. | |
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MedLine Citation:
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PMID: 22245822 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: Diabetes mellitus and chemotherapy use are well-known factors that can affect success after microvascular repair. Although many studies have investigated each factor individually, no study exists on their combined effect. The aim of our study was to investigate the effects of preoperative vinblastine, a vinca alkaloid, on the healing of microvascular anastomosis in diabetic and non-diabetic rats. METHODS: In this study, 144 Sprague Dawley rats were assigned randomly and equally into experimental or control groups. The experimental group consisted of 72 rats which were made diabetic by alloxan injections. Diabetes was confirmed by glycosuria (>2%) and elevated plasma glucose (>300 mg/100 ml) after three days of alloxan injections. The experimental group then received a single dose of intraperitoneal vinblastine. After applying the medication, the two main groups were divided into three subgroups. For each group, we performed end-to-end femoral artery anastomosis on Day 7, 14, and 21, respectively. We further divided each subgroup equally into three smaller groups to test patency and took biopsies at Day 7, 14 and 21, respectively. Histopathologic evaluation was carried out. RESULTS: The comparison of patency tests and pathologic examination indicated that there was no statistically significant difference between the two groups. CONCLUSION: The negative effects of diabetes and the administration of vinblastine did not significantly influence anastomosis healing. |
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Authors:
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Semra Karşıdağ; Soner Tatlıdede; Uğur Tosun; Kemalettin Yıldız; Fevziye Kabukçuoğlu; Arzu Akçal |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta orthopaedica et traumatologica turcica Volume: 45 ISSN: 1017-995X ISO Abbreviation: Acta Orthop Traumatol Turc Publication Date: 2011 |
Date Detail:
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Created Date: 2012-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9424806 Medline TA: Acta Orthop Traumatol Turc Country: Turkey |
Other Details:
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Languages: eng Pagination: 446-52 Citation Subset: IM |
Affiliation:
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Department of Plastic and Reconstructive Surgery, Şişli Etfal Training and Research Hospital, İstanbul, Turkey. semrakarsidag@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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