Document Detail

Effects of verapamil on left ventricular diastolic filling in children with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  3341224     Owner:  NLM     Status:  MEDLINE    
The effects of oral verapamil on resting left ventricular (LV) diastolic filling were examined in 10 children and adolescents with hypertrophic cardiomyopathy. Measurements of diastolic filling were made from gated technetium-99m radionuclide angiograms with postbeat rejection of data outside a 5% RR-interval window. LV time-activity curves were generated and the rapid-filling phase fit with a 3 degrees polynomial to calculate the peak filling rate and the time from end-systole to the point of peak filling. All patients had a radionuclide angiogram performed before and after 0.25 to 3 years of oral verapamil therapy. Verapamil did not change the LV ejection fraction but increased the peak filling rate (3.24 +/- 0.15 to 4.62 +/- 1.05 end-diastolic volume/s,p less than 0.01) and reduced the time to peak filling (217 +/- 57 to 168 +/- 63 ms, p less than 0.01). An increase in exercise endurance as measured by exercise treadmill test and subjective symptomatic improvement were also seen after verapamil therapy. Thus, in children with hypertrophic cardiomyopathy, symptomatic improvement and LV diastolic filling parameters improved with long-term oral verapamil.
E M Shaffer; A P Rocchini; R L Spicer; J Juni; R Snider; D C Crowley; A Rosenthal
Related Documents :
9555874 - Distribution and synthesis of apolipoprotein j in the atherosclerotic aorta.
2015124 - Estimation of doppler gradients at rest and during exercise in patients with recoarctat...
22407494 - The effects of resistance training on apob/apoa-i ratio, lp(a) and inflammatory markers...
15246914 - Magnitude of left atrial v wave is the determinant of exercise capacity in patients wit...
2677294 - Indomethacin reduces the risks of severe intraventricular hemorrhage.
11543414 - Resistance exercise countermeasures for space flight: implications of training specific...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  61     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-21     Completed Date:  1988-03-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  413-7     Citation Subset:  AIM; IM    
Department of Pediatric Cardiology, Mott Children's Hospital, University of Michigan Medical Center, Ann Arbor 48109-0204.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Cardiomyopathy, Hypertrophic / drug therapy*,  radionuclide imaging
Exercise Test
Follow-Up Studies
Heart / radionuclide imaging
Myocardial Contraction / drug effects*
Radionuclide Angiography
Technetium / diagnostic use
Time Factors
Verapamil / therapeutic use*
Grant Support
1RR-00042-25/RR/NCRR NIH HHS
Reg. No./Substance:
52-53-9/Verapamil; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Current and future strategies in the treatment of hypertension.
Next Document:  Cardiac malformations in relatives of children with truncus arteriosus or interruption of the aortic...