Document Detail


Effects of verapamil on left ventricular diastolic filling in children with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  3341224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of oral verapamil on resting left ventricular (LV) diastolic filling were examined in 10 children and adolescents with hypertrophic cardiomyopathy. Measurements of diastolic filling were made from gated technetium-99m radionuclide angiograms with postbeat rejection of data outside a 5% RR-interval window. LV time-activity curves were generated and the rapid-filling phase fit with a 3 degrees polynomial to calculate the peak filling rate and the time from end-systole to the point of peak filling. All patients had a radionuclide angiogram performed before and after 0.25 to 3 years of oral verapamil therapy. Verapamil did not change the LV ejection fraction but increased the peak filling rate (3.24 +/- 0.15 to 4.62 +/- 1.05 end-diastolic volume/s,p less than 0.01) and reduced the time to peak filling (217 +/- 57 to 168 +/- 63 ms, p less than 0.01). An increase in exercise endurance as measured by exercise treadmill test and subjective symptomatic improvement were also seen after verapamil therapy. Thus, in children with hypertrophic cardiomyopathy, symptomatic improvement and LV diastolic filling parameters improved with long-term oral verapamil.
Authors:
E M Shaffer; A P Rocchini; R L Spicer; J Juni; R Snider; D C Crowley; A Rosenthal
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  61     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-03-21     Completed Date:  1988-03-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  413-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatric Cardiology, Mott Children's Hospital, University of Michigan Medical Center, Ann Arbor 48109-0204.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Cardiomyopathy, Hypertrophic / drug therapy*,  radionuclide imaging
Child
Exercise Test
Follow-Up Studies
Heart / radionuclide imaging
Humans
Myocardial Contraction / drug effects*
Radionuclide Angiography
Technetium / diagnostic use
Time Factors
Verapamil / therapeutic use*
Grant Support
ID/Acronym/Agency:
1RR-00042-25/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
52-53-9/Verapamil; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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