| Effects of verapamil and bepridil on occlusion and reperfusion arrhythmias in the canine heart. | |
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MedLine Citation:
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PMID: 3876883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of verapamil and bepridil on occlusion and reperfusion ventricular arrhythmias including ventricular fibrillation (VF) were studied in a canine model. The control group consisted of 27 dogs. 30 dogs received intravenous verapamil (0.2 mg/kg/3 min followed by a continuous infusion of 0.01 mg/kg/min for 15 min). 18 dogs received bepridil (0.5 mg/kg/min for 10 min). The left anterior descending coronary artery was occluded in one step 8 min after the commencement of verapamil administration and 5 min after the termination of bepridil infusion. The incidence of ventricular arrhythmias during the occlusion period was 14 (VF, 5/14), 13 (VF, 0/13) and 14 (VF, 9/14) in the control, verapamil and bepridil groups, respectively. The frequencies of reperfusion VF were 8/24 (33%), 4/30 (13.3%) and 0/13 (0%), respectively. It was concluded that (a) verapamil effectively prevents occlusion but not reperfusion VF and (b) bepridil has an arrhythmogenic effect in the ischemic canine heart but reduces the incidence of reperfusion VF. |
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Authors:
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A Pelleg; Y Pardo; B Belhassen; B Shargordsky; A Chagnac; S Laniado |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cardiology Volume: 72 ISSN: 0008-6312 ISO Abbreviation: Cardiology Publication Date: 1985 |
Date Detail:
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Created Date: 1985-11-27 Completed Date: 1985-11-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1266406 Medline TA: Cardiology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 193-201 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / drug therapy*, etiology, prevention & control Bepridil Constriction Coronary Vessels Dogs Female Heart Rate / drug effects Male Pyrrolidines / blood, therapeutic use*, toxicity Ventricular Fibrillation / drug therapy, etiology, prevention & control Verapamil / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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IF32 05947//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Pyrrolidines; 52-53-9/Verapamil; 64706-54-3/Bepridil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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