Document Detail

Effects of ventilation style on surfactant metabolism and treatment response in preterm lambs.
MedLine Citation:
PMID:  9476883     Owner:  NLM     Status:  MEDLINE    
We investigated whether the style of ventilation would influence respiratory physiology or surfactant metabolism in surfactant-treated preterm lambs. Preterm lambs were delivered at 131 +/- 1 d gestation and treated with an organic solvent extract of sheep surfactant (100 mg/kg). The lambs were randomized to ventilation peiods of 2 h, 5 h, 10 h, or 24 h, and to ventilation with a low rate (15 breaths/min) and high VT (15 ml/kg), with a high rate (50 breaths/min) and low VT (8 ml/kg), or with high-frequency oscillatory ventilation (HFOV). Gas exchange and lung volumes were similar across time and for the different ventilation styles. Saturated phosphatidylcholine (SatPC) in alveolar lavage was lower for the HFOV group than for the other ventilation groups at 10 h and 24 h. The rate of loss of surfactant protein B (SP-B) from these preterm animals' lungs was slow and not influenced by ventilation style. The percentages of surfactants in large-aggregate forms were not changed by style of ventilation, and the large-aggregate surfactants had excellent function when tested in surfactant-deficient preterm rabbits. Alveolar lavage protein was low (30 ml/kg), and tissue hyaluronan did not change with time or ventilation style. In preterm lambs ventilated without causing injury, the extreme styles of ventilation examined in the study had minimal effects on lung function, surfactant function, or surfactant metabolism.
M Ikegami; K Wada; G A Emerson; C M Rebello; R E Hernandez; A H Jobe
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  157     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-12     Completed Date:  1998-03-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  638-44     Citation Subset:  AIM; IM    
Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California, USA.
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MeSH Terms
Animals, Newborn / physiology*
Gestational Age
Proteolipids / pharmacokinetics
Pulmonary Surfactants / metabolism*,  pharmacokinetics,  pharmacology*,  physiology
Respiration / physiology*
Grant Support
Reg. No./Substance:
0/Proteolipids; 0/Pulmonary Surfactants

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