| Effects of vehicles and enhancers on transdermal delivery of clebopride. | |
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MedLine Citation:
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PMID: 17958335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of vehicles and penetration enhancers on the skin permeation of clebopride were evaluated using Franz type diffusion cells fitted with excised rat dorsal skins. The binary vehicle system, diethylene glycol monoethyl ether/isopropyl myristate (40/60, w/w), significantly enhanced the skin permeation rate of clebopride. The skin permeation enhancers, oleic acid and ethanol when used in the binary vehicle system, resulted in relatively high clebopride skin permeation rates. A gel formulation consisting of 1.5% (w/w) clebopride, 5% (w/w) oleic acid, and 7% (w/w) gelling agent with the binary vehicle system resulted in a permeation rate of 28.90 microg/cm2/h. Overall, these results highlight the potential of clebopride formulation for the transdermal route. |
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Authors:
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Yun-Seok Rhee; Jai-Yong Huh; Chun-Woong Park; Tae-Young Nam; Koog-Ryul Yoon; Sang-Cheol Chi; Eun-Seok Park |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives of pharmacal research Volume: 30 ISSN: 0253-6269 ISO Abbreviation: Arch. Pharm. Res. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-10-25 Completed Date: 2007-11-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8000036 Medline TA: Arch Pharm Res Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 1155-61 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Animals Benzamides / administration & dosage*, chemistry, pharmacokinetics Male Permeability Rats Rats, Sprague-Dawley Skin Absorption* Solubility Vehicles |
| Chemical | |
Reg. No./Substance:
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0/Benzamides; 0/Vehicles; 55905-53-8/clebopride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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