Document Detail


Effects of vehicles and enhancers on transdermal delivery of clebopride.
MedLine Citation:
PMID:  17958335     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of vehicles and penetration enhancers on the skin permeation of clebopride were evaluated using Franz type diffusion cells fitted with excised rat dorsal skins. The binary vehicle system, diethylene glycol monoethyl ether/isopropyl myristate (40/60, w/w), significantly enhanced the skin permeation rate of clebopride. The skin permeation enhancers, oleic acid and ethanol when used in the binary vehicle system, resulted in relatively high clebopride skin permeation rates. A gel formulation consisting of 1.5% (w/w) clebopride, 5% (w/w) oleic acid, and 7% (w/w) gelling agent with the binary vehicle system resulted in a permeation rate of 28.90 microg/cm2/h. Overall, these results highlight the potential of clebopride formulation for the transdermal route.
Authors:
Yun-Seok Rhee; Jai-Yong Huh; Chun-Woong Park; Tae-Young Nam; Koog-Ryul Yoon; Sang-Cheol Chi; Eun-Seok Park
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pharmacal research     Volume:  30     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-25     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1155-61     Citation Subset:  IM    
Affiliation:
College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Animals
Benzamides / administration & dosage*,  chemistry,  pharmacokinetics
Male
Permeability
Rats
Rats, Sprague-Dawley
Skin Absorption*
Solubility
Vehicles
Chemical
Reg. No./Substance:
0/Benzamides; 0/Vehicles; 55905-53-8/clebopride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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