Document Detail

Effects of vasopressin on portal-systemic collaterals of cirrhotic rats.
MedLine Citation:
PMID:  15841719     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Arginine vasopressin (AVP) exerts a constrictive effect on the portal-systemic collaterals of non-cirrhotic portal hypertensive rats, but its effect on cirrhotic rats is unknown. The aim of this study was to investigate the response of AVP and the modulatory roles of nitric oxide and prostaglandin on collaterals of common bile duct-ligated (BDL) cirrhotic rats. MATERIAL AND METHODS: The collateral vascular responsiveness to graded concentrations of AVP (10(-10) - 3 x 10(-7) M) was tested by an in situ collateral perfusion system pretreated with Nomega-nitro-L-arginine (L-NNA, 100 microM), indomethacin (INDO, 10 microM), or both. The collateral responses to AVP with the pretreatment of a vasopressin V1 receptor antagonist d(CH2)5Tyr(Me) arginine vasopressin or a V2 receptor agonist 1-desamino-8-D-arginine vasopressin (DDAVP, 10(-10) - 3 x 10(-7) M) were also evaluated. RESULTS: The perfusion pressure of collaterals was significantly increased by AVP, and this effect was inhibited by the addition of the V1 receptor antagonist. DDAVP had no effect on the collaterals. Incubation with L-NNA or L-NNA plus INDO, but not INDO alone, significantly potentiated the constrictive effects of AVP. The constrictive effect of AVP in the combination group was similar to that in the L-NNA alone group. CONCLUSIONS: The results show that AVP produces a direct vasoconstrictive effect on the portal-systemic collaterals of BDL cirrhotic rats. The constrictive effect of AVP is mediated by the vasopressin V1, instead of V2, receptors. Nitric oxide may play a more important role than prostaglandin in modulating the collateral vascular response to AVP in BDL cirrhotic rats.
Che-Chang Chan; Sun-Sang Wang; Fa-Yauh Lee; Full-Young Chang; Han-Chieh Lin; Ming-Chieh Hou; Hui-Chun Huang; Shou-Dong Lee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  40     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-04-21     Completed Date:  2005-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  83-9     Citation Subset:  IM    
Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taiwan, Republic of China.
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MeSH Terms
Collateral Circulation / drug effects*,  physiology
Disease Models, Animal
Liver Circulation / drug effects
Liver Cirrhosis / drug therapy*,  pathology
Nitric Oxide / metabolism
Portal System / drug effects*,  physiology
Prostaglandins / metabolism
Random Allocation
Rats, Sprague-Dawley
Sensitivity and Specificity
Vasopressins / pharmacology*
Reg. No./Substance:
0/Prostaglandins; 10102-43-9/Nitric Oxide; 11000-17-2/Vasopressins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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