| Effects of a vasopressin antagonist with combined antipressor and antiantidiuretic activities in rats with left ventricular dysfunction. | |
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MedLine Citation:
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PMID: 2404626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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These experiments assessed the hemodynamic and aquaretic effects of an arginine vasopressin (AVP) antagonist with dual V1V2-receptor inhibiting properties in rats with congestive heart failure resulting from ischemic cardiomyopathy. The compound d(CH2)5-D-Tyr(Et)VAVP was used in these studies. Rats with limited or extensive myocardial infarcts (i.e., with less than 50% or greater than 66% necrosis of the left ventricular wall, respectively, induced by left coronary ligation) and sham-operated controls received the AVP antagonist (100 micrograms/kg i.v.) 4 weeks later. This agent produced an 18% increase in cardiac output (p less than 0.05) and 13% decrease in systemic vascular resistance in the severely damaged rats, both changes being significantly different from those seen in the normal controls or the rats with limited infarcts. All animals exhibited increases in urinary output of 4-10-fold over baseline. We conclude that the hemodynamic and renal effects of this agent are beneficial in animals with left ventricular dysfunction. |
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Authors:
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R A Mulinari; I Gavras; Y X Wang; R Franco; H Gavras |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 81 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-02-23 Completed Date: 1990-02-23 Revised Date: 2013-03-06 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 308-11 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Boston University School of Medicine, MA 02118. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacology* Arginine Vasopressin / analogs & derivatives*, pharmacology Diuresis / drug effects* Heart Failure / physiopathology* Male Rats Rats, Inbred Strains Ultrasonography Vascular Resistance / drug effects Vasopressins / antagonists & inhibitors* |
| Grant Support | |
ID/Acronym/Agency:
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HL-18-318/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 11000-17-2/Vasopressins; 113-79-1/Arginine Vasopressin; 77453-01-1/1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid)-2-(O-ethyl-Tyr)-4-Val-arginine vasopressin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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